Bornemann L D, Colburn W A
J Toxicol Environ Health. 1985;16(3-4):631-9. doi: 10.1080/15287398509530769.
A pharmacokinetic model was developed to describe the disposition of lead in the rat. The model can be used to predict the effect of acute high-dose as well as low-dose exposure to lead. These results suggest that the model should be able to predict the effect of chronic low-dose exposures as well. Plasma, bone, liver, and bile profiles were generated from this model using previously published data. The results obtained supported the existing theory that lead demonstrates a dose-dependent pharmacokinetic profile in the rat.
建立了一个药代动力学模型来描述大鼠体内铅的处置情况。该模型可用于预测急性高剂量以及低剂量铅暴露的影响。这些结果表明，该模型应该也能够预测慢性低剂量暴露的影响。利用先前发表的数据从该模型生成了血浆、骨骼、肝脏和胆汁的分布图。所获得的结果支持了现有的理论，即铅在大鼠体内呈现出剂量依赖性药代动力学特征。
