Silbergeld E K, Sauk J, Somerman M, Todd A, McNeill F, Fowler B, Fontaine A, van Buren J
Department of Epidemiology, University of Maryland, Baltimore 21201.
Neurotoxicology. 1993 Summer-Fall;14(2-3):225-36.
The primary site of lead storage is in bone but relatively little attention has focused on this physiological compartment. Recent advances in measurement technology now permit the direct in vivo quantitative measurement of lead in bone, and this measure has great use in clinical and epidemiologic studies. Lead in bone is not a physiological sink, but can be mobilized back into the circulation in response to normal or pathological changes in mineral metabolism. Bone lead may be a significant source of target organ exposure under certain conditions, such as pregnancy, kidney disease, and menopause. Finally, the accumulation of lead in bone cells may have toxic consequences for bone status, and some of the mechanisms by which lead could affect bone mineral metabolism may also play a role in other target organ effects of lead.
铅储存的主要部位是骨骼，但相对而言，很少有研究关注这个生理区室。测量技术的最新进展现在使得能够在体内直接定量测量骨骼中的铅，并且这项测量在临床和流行病学研究中具有很大用途。骨骼中的铅不是一个生理性储存库，但可因矿物质代谢的正常或病理变化而重新进入循环。在某些情况下，如怀孕、肾脏疾病和更年期，骨铅可能是靶器官暴露的一个重要来源。最后，铅在骨细胞中的蓄积可能对骨骼状态产生毒性后果，并且铅影响骨矿物质代谢的一些机制也可能在铅对其他靶器官的作用中发挥作用。
