Hasanbeyzade Sabir
Dermatology and Venerology Department, Hitit University, Erol Olçok Training and Research Hospital, Çorum, Türkiye.
J Cosmet Dermatol. 2025 Sep;24(9):e70410. doi: 10.1111/jocd.70410.
Acne vulgaris is an inflammatory disease affecting the pilosebaceous unit, which also has psychological effects.
Our aim in our study is to compare the recovery levels and side effect profiles of patients diagnosed with acne during pregnancy and who used topical erythromycin, clindamycin, or topical azelaic acid.
After ethical approval was obtained for the study, the files of patients who applied to the outpatient clinic with acne complaints in 2018-2022 were retrospectively examined, and the files of 75 pregnant patients who used topical erythromycin, 96 who used clindamycin, and 26 who used azelaic acid were included in the study. Pre- and post-treatment IGA values, lesion numbers, side effects during the treatment process, and patient satisfaction levels were examined.
When the groups were compared in terms of IGA value at the end of treatment and percentage improvements in all lesion numbers, it was seen that there was more improvement in the group using azelaic acid than the others (p < 0.001 for both). When the groups were compared in terms of side effects, no difference was found (p = 0.093). When the groups were compared in terms of satisfaction levels, there were significantly more patients who were very satisfied in the azelaic acid group (p < 0.001).
As a result of the study, we see that azelaic acid is more successful in terms of both effectiveness and patient satisfaction. Therefore, azelaic acid is a good option in the treatment of mild to moderate acne during pregnancy.
寻常痤疮是一种影响毛囊皮脂腺单位的炎症性疾病，它也具有心理影响。
我们研究的目的是比较在孕期被诊断为痤疮且使用外用红霉素、克林霉素或外用壬二酸的患者的恢复水平和副作用情况。
在获得该研究的伦理批准后，回顾性检查了2018年至2022年因痤疮症状到门诊就诊患者的病历，纳入了75名使用外用红霉素的孕妇、96名使用克林霉素的孕妇以及26名使用壬二酸的孕妇的病历。检查了治疗前后的IGA值、皮损数量、治疗过程中的副作用以及患者满意度水平。
在治疗结束时比较各组的IGA值以及所有皮损数量的改善百分比时，发现使用壬二酸的组比其他组改善更多（两者均p < 0.001）。在比较各组的副作用时，未发现差异（p = 0.093）。在比较各组的满意度水平时，壬二酸组中非常满意的患者明显更多（p < 0.001）。
作为研究结果，我们发现壬二酸在有效性和患者满意度方面都更成功。因此，壬二酸是孕期治疗轻度至中度痤疮的一个良好选择。
