National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore.
Drugs. 2013 Jun;73(8):779-87. doi: 10.1007/s40265-013-0060-0.
Acne vulgaris is a common problem encountered by pregnant and lactating women. Unfortunately, in clinical practice, treatment is often not optimized as a result of the lack of safety data and unified recommendations on the use of the various anti-acne therapies. In this narrative review, current data on their safety is summarized. We recommend the use of topical medications as first-line treatment for acne vulgaris in pregnant and lactating women. These include antibiotics (erythromycin, clindamycin, metronidazole and dapsone), benzoyl peroxide, azelaic acid and salicylic acid. Oral agents and/or light-based therapy may be considered as second-line treatment. The former consists of oral macrolides (erythromycin and azithromycin), cephalexin or zinc compounds. Blue-violet or red light phototherapy may be used as monotherapy or in addition to topical and/or oral therapies. Hormonal therapy, antibiotics consisting of tetracyclines, co-trimoxazole and fluoroquinolones, and both oral and topical retinoids should be avoided.
寻常痤疮是妊娠和哺乳期妇女常见的问题。遗憾的是，由于缺乏安全性数据和各种痤疮治疗方法的统一建议，在临床实践中，治疗往往无法得到优化。在这篇叙述性综述中，总结了目前关于其安全性的数据。我们建议在妊娠和哺乳期妇女中使用局部药物作为寻常痤疮的一线治疗。这些药物包括抗生素（红霉素、克林霉素、甲硝唑和氨苯砜）、过氧化苯甲酰、壬二酸和水杨酸。口服药物和/或光疗可作为二线治疗。前者包括口服大环内酯类（红霉素和阿奇霉素）、头孢氨苄或锌化合物。蓝-紫光或红光光疗可作为单一疗法或与局部和/或口服治疗联合使用。应避免使用激素治疗、包含四环素、复方磺胺甲噁唑和氟喹诺酮类的抗生素以及口服和局部维甲酸。
