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Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa.评论：在南非口服轮状病毒疫苗接种情况不佳的婴儿中，唾液铁调素及其诱导剂白细胞介素6以及I型干扰素的表达显著升高。
Front Immunol. 2025 Aug 12;16:1651751. doi: 10.3389/fimmu.2025.1651751. eCollection 2025.
2
Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa.在南非口服轮状病毒疫苗接种情况不佳的婴儿中，唾液中铁调素及其诱导剂白细胞介素6以及I型干扰素的表达显著升高。
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Abundance of single filamentous bacteria, and expression of differentiated Th17 cells, their signature cytokine IL-17 A, and retinoic acid receptor are predictive of poor rotavirus vaccine take.单丝状细菌的丰度、分化的Th17细胞的表达、其标志性细胞因子IL-17A以及视黄酸受体可预测轮状病毒疫苗接种效果不佳。
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本文引用的文献

1
Hepcidin promotes oral ulcer healing via amphiregulin production in rats.铁调素通过促进大鼠双调蛋白的产生来促进口腔溃疡愈合。
J Dent Sci. 2025 Jul;20(3):1562-1570. doi: 10.1016/j.jds.2024.12.001. Epub 2024 Dec 13.
2
Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa.在南非口服轮状病毒疫苗接种情况不佳的婴儿中，唾液中铁调素及其诱导剂白细胞介素6以及I型干扰素的表达显著升高。
Front Immunol. 2025 May 16;16:1517893. doi: 10.3389/fimmu.2025.1517893. eCollection 2025.
3
Non-invasive iron deficiency diagnosis: a saliva-based approach using capillary flow microfluidics.非侵入性缺铁诊断：基于毛细管流动微流控技术的唾液检测方法。
Anal Methods. 2024 Apr 25;16(16):2489-2495. doi: 10.1039/d3ay01933k.
4
Epidemiology of Rotavirus in Humans, Animals, and the Environment in Africa: A Systematic Review and Meta-analysis.非洲人类、动物和环境中轮状病毒的流行病学：系统评价和荟萃分析。
J Infect Dis. 2024 May 15;229(5):1470-1480. doi: 10.1093/infdis/jiad500.
5
Hepcidin and Iron in Health and Disease.《健康与疾病中的铁调素与铁》
Annu Rev Med. 2023 Jan 27;74:261-277. doi: 10.1146/annurev-med-043021-032816. Epub 2022 Jul 29.
6
Ferroptosis in viral infection: the unexplored possibility.病毒感染中的铁死亡：未被探索的可能性。
Acta Pharmacol Sin. 2022 Aug;43(8):1905-1915. doi: 10.1038/s41401-021-00814-1. Epub 2021 Dec 6.
7
Evaluation of Serum and Salivary Iron and Ferritin Levels in Children with Dental Caries: A Meta-Analysis and Trial Sequential Analysis.龋齿儿童血清和唾液铁及铁蛋白水平的评估：一项荟萃分析和试验序贯分析
Children (Basel). 2021 Nov 11;8(11):1034. doi: 10.3390/children8111034.
8
Effect of hepcidin antagonists on anemia during inflammatory disorders.炎症性疾病期间铁调素拮抗剂对贫血的影响。
Pharmacol Ther. 2021 Oct;226:107877. doi: 10.1016/j.pharmthera.2021.107877. Epub 2021 Apr 22.
9
Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.呼吸道感染导致铁调素介导的铁吸收受阻，从而导致非洲儿童缺铁性贫血。
Sci Adv. 2019 Mar 27;5(3):eaav9020. doi: 10.1126/sciadv.aav9020. eCollection 2019 Mar.
10
Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus.慢性牙周炎合并2型糖尿病患者的血清和唾液铁蛋白及铁调素水平
BMC Oral Health. 2018 Apr 10;18(1):63. doi: 10.1186/s12903-018-0524-4.

Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa.

作者信息

Słomka Artur

机构信息

Department of Pathophysiology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Department of Digital Medicine, Implementation & Innovation, National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland.

出版信息

Front Immunol. 2025 Aug 12;16:1651751. doi: 10.3389/fimmu.2025.1651751. eCollection 2025.

DOI:10.3389/fimmu.2025.1651751
PMID:40873589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12378090/
Abstract
摘要