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揭示DNA修复的作用机制：光笼化糖基化酶复合物的结构洞察

Illuminating DNA repair in action: structural insights into a photocaged glycosylase complex.

作者信息

Suga Michihiro

机构信息

Research Institute for Interdisciplinary Science, Okayama University, Okayama 700-8530, Japan.

出版信息

IUCrJ. 2025 Sep 1;12(Pt 5):513-514. doi: 10.1107/S2052252525007353.

DOI:10.1107/S2052252525007353
PMID:40874471
Abstract

Structural analysis of the co-crystal between human DNA glycosylase hOGG1 and a light-sensitive substrate analog highlights its utility as a platform for real-time observation of catalytic dynamics.

摘要

人类DNA糖基化酶hOGG1与光敏感底物类似物共晶体的结构分析突出了其作为实时观察催化动力学平台的实用性。

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本文引用的文献

1
Revisiting the co-crystal structure of a DNA glycosylase with photocaged substrate: a suitable time-resolved crystallography target?重新审视DNA糖基化酶与光笼蔽底物的共晶体结构：一个合适的时间分辨晶体学研究对象？
IUCrJ. 2025 Sep 1;12(Pt 5):515-522. doi: 10.1107/S2052252525006062.
2
Oxygen-evolving photosystem II structures during S-S-S transitions.放氧光合作用系统 II 结构在 S-S-S 转变期间。
Nature. 2024 Feb;626(7999):670-677. doi: 10.1038/s41586-023-06987-5. Epub 2024 Jan 31.
3
A three-dimensional movie of structural changes in bacteriorhodopsin.
三维电影中的紫膜蛋白结构变化。
Science. 2016 Dec 23;354(6319):1552-1557. doi: 10.1126/science.aah3497.
4
Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein.时分辨连续晶体学捕获光致变色黄色蛋白的高分辨率中间体。
Science. 2014 Dec 5;346(6214):1242-6. doi: 10.1126/science.1259357.
5
Trapping and structural elucidation of a very advanced intermediate in the lesion-extrusion pathway of hOGG1.捕获并阐明人8-氧代鸟嘌呤DNA糖苷酶1（hOGG1）损伤挤出途径中一个非常高级的中间体的结构
J Am Chem Soc. 2008 Jun 25;130(25):7784-5. doi: 10.1021/ja800821t. Epub 2008 May 29.