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瑞典人群中某些重要放射性核素的年龄和性别特异性癌症风险预测——采用更新后的橡树岭国家实验室慢性暴露计算方法

Age- and sex-specific cancer risk predictions for some important radionuclides in a Swedish population-use of the updated ORNL computation method for chronic exposure.

作者信息

Andersson Martin, Leggett Richard W, Eckerman Keith, Mattsson Sören

机构信息

Department of Radiation Physics, Sahlgrenska Cancer Center, University of Gothenburg, Sahlgrenska Universitetssjukhuset, Gula stråket 2B, Göteborg 41345, Sweden.

Medical Radiation Physics Malmö, Department of Translational Medicine, Lund University, Skåne University Hospital, SUS Malmö, Inga Marie Nilssons gata 47, Malmö SE-205 02, Sweden.

出版信息

Radiat Prot Dosimetry. 2025 Aug 26;201(13-14):966-973. doi: 10.1093/rpd/ncaf045.

Abstract

Radiation dosimetry and cancer risk estimations are central to virtually all radiation safety applications, optimization, and research. These estimates relate to various exposure situations including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new methodology to handle the dosimetry of an acute/single intake of radionuclides. To expand this to a chronic exposure over a lifetime or during shorter periods, Oak Ridge National Laboratory (ORNL) applies a methodology based on the ICRP primary data with additional lifetime population-based radiogenic cancer risk estimations involving age- and gender-specific intake rates and organ specific cancer risk models. The releases of unwanted artificial radionuclides in the environment could have a big impact on society, both locally and globally. Such an exposure may occur over an extended time period, and the derived cancer risk coefficients should reflect that possibility. In the present study, cancer risk coefficients are calculated for the Swedish population for 14C, 137Cs, 90Sr, 131I, and 60Co, for internal exposure through air, food, and water and external exposure from air, water, surface, and soil.

摘要

辐射剂量测定和癌症风险估计几乎是所有辐射安全应用、优化及研究的核心内容。这些估计涉及各种照射情况,包括计划中的、现有的和紧急情况。国际放射防护委员会(ICRP)已制定了一种新方法来处理放射性核素急性/单次摄入的剂量测定。为了将其扩展到一生或较短时期内的慢性照射,橡树岭国家实验室(ORNL)应用了一种基于ICRP原始数据的方法,并进行了额外的基于终生人群的放射性癌症风险估计,其中涉及年龄和性别特异性摄入率以及器官特异性癌症风险模型。环境中意外人工放射性核素的释放可能会对社会产生重大影响,无论是在本地还是全球范围内。这种照射可能会在较长时间段内发生,而得出的癌症风险系数应反映这种可能性。在本研究中,针对瑞典人群计算了通过空气、食物和水的内照射以及空气、水、地表和土壤的外照射情况下,14C、137Cs、90Sr、131I和60Co的癌症风险系数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea5/12392900/c1afe655da39/ncaf045f1.jpg

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