Misawa M, Ohmori S, Yanaura S
Jpn J Pharmacol. 1985 Oct;39(2):241-50. doi: 10.1254/jjp.39.241.
Effects of bromhexine and pilocarpine on the secretions of submaxillary saliva in dogs and of tears in rabbits were investigated including their effects on lysozyme activity in an attempt to elucidate the efficacy of bromhexine on Sjögren's syndrome. Pilocarpine (0.3 mg/kg, p.o.) significantly increased spontaneous salivary flow rate, but bromhexine (20 and 40 mg/kg, p.o.) had almost no influence on spontaneous salivary flow rate. Pilocarpine increased total protein, saccharide, lysozyme and IgA secretions in saliva under electrical stimulation of the chorda tympani. Bromhexine did more markedly increase total lysozyme and IgA secretions in saliva, with minor increases in total protein and saccharide secretions. Pilocarpine (0.4 mg/kg, i.v.) had almost no influence on lysozyme concentration in tears, whereas it markedly increased tear secretion volume leading to an increase in total lysozyme secretion. On the other hand, bromhexine (4 and 8 mg/kg, i.v.) significantly increased both lysozyme concentration and total lysozyme secretion in tears from 50 min after injection, without influencing tear secretion volume. From these findings, it is suggested that bromhexine may work effectively on Sjögren's syndrome by acting to accelerate the secretions of lysozyme and IgA in saliva and tears, which are known to have antiinflammatory and bacteriocidal effects.
研究了溴己新和毛果芸香碱对犬颌下唾液分泌及兔泪液分泌的影响，包括它们对溶菌酶活性的影响，以阐明溴己新对干燥综合征的疗效。毛果芸香碱（0.3mg/kg，口服）显著增加唾液自发分泌率，但溴己新（20和40mg/kg，口服）对唾液自发分泌率几乎没有影响。在鼓索神经电刺激下，毛果芸香碱增加唾液中总蛋白、糖类、溶菌酶和IgA的分泌。溴己新更显著地增加唾液中总溶菌酶和IgA的分泌，总蛋白和糖类分泌略有增加。毛果芸香碱（0.4mg/kg，静脉注射）对泪液中溶菌酶浓度几乎没有影响，而它显著增加泪液分泌量，导致总溶菌酶分泌增加。另一方面，溴己新（4和8mg/kg，静脉注射）在注射后50分钟显著增加泪液中溶菌酶浓度和总溶菌酶分泌，而不影响泪液分泌量。从这些发现可以推测，溴己新可能通过促进唾液和泪液中溶菌酶和IgA的分泌而有效作用于干燥综合征，已知溶菌酶和IgA具有抗炎和杀菌作用。
