Meerson F Z, Belkina L M, Diusenov S S, Ustinova E E, Shabunina E V
Kardiologiia. 1985 Oct;25(10):29-34.
Electrical ventricular fibrillation threshold (VFT) was determined, using programmed isolated stimuli on the left-ventricular apex, in male Wistar rats at different times after 10 hours' immobilization stress (IS). The VFT decrease reached a maximum of 48% 12 hours after IS. Cardiac sensitivity to the inhibiting vagal influence was increased considerably at the same time. The adaptation to short episodes of IS over 6 days, intermittent exposure to high-altitude hypoxia (5 hours daily at a 5000 m "altitude" for 40 days) and the antioxidant ionol (50 mg/kg) prevented IS-induced fibrillation threshold decrease. In cases of coronary arterial ligation in waking animals, the antioxidant ionol reduced fourfold the mortality associated with ventricular fibrillation and raised the spontaneous defibrillation rate from 28% to 72%. Possible mechanisms of these phenomena are discussed.
在雄性Wistar大鼠经10小时制动应激（IS）后的不同时间，通过对左心室心尖施加程控孤立刺激来测定心室颤动阈值（VFT）。VFT降低在IS后12小时达到最大降幅48%。同时，心脏对迷走神经抑制作用的敏感性显著增加。对持续6天的短时间IS、间歇性暴露于高海拔低氧环境（在“海拔”5000米处每天5小时，共40天）以及抗氧化剂维生素E（50毫克/千克）的适应性，可防止IS诱导的颤动阈值降低。在清醒动物冠状动脉结扎的情况下，抗氧化剂维生素E使与心室颤动相关的死亡率降低了四倍，并将自发除颤率从28%提高到72%。讨论了这些现象的可能机制。
