O'Donnell Valerie B
School of Medicine, Cardiff University, Cardiff, UK.
J Biol Chem. 2025 Aug 26;301(10):110629. doi: 10.1016/j.jbc.2025.110629.
Oxylipins represent large families of bioactive lipids generated through the oxygenation of fatty acids. Although originally discovered almost 100 years ago, significant interest in these lipids continues today with many important discoveries on their structures and functions still being made, particularly in regards to mammalian biology. This review will highlight some aspects of the current status of the field, focusing on recent findings that continue to challenge our views about how oxylipins are made and act in human health and disease. Areas to be covered include: an update on the ever-expanding roles of prostaglandinE in cancer, octadecanoid structures and nomenclature, complex forms of oxylipins, and challenges and considerations for oxylipin analysis including potential clinical utility.
氧化脂质是通过脂肪酸的氧化作用产生的一大类生物活性脂质。尽管氧化脂质早在近100年前就被发现，但时至今日，人们对这些脂质仍有着浓厚的兴趣，关于它们的结构和功能仍有许多重要发现不断涌现，尤其是在哺乳动物生物学领域。本综述将重点介绍该领域的一些现状，着重关注那些不断挑战我们对氧化脂质在人类健康和疾病中生成及作用方式看法的最新研究结果。涵盖的领域包括：前列腺素E在癌症中不断扩展的作用的最新进展、十八烷酸类化合物的结构和命名、氧化脂质的复杂形式，以及氧化脂质分析面临的挑战和考量，包括潜在的临床应用价值。
