Lazarus Maja, Plançon Abigail R L, Orct Tatjana, Ferenčaković Maja, Crnić Andreja Prevendar
Division of Occupational and Environmental Health, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, Croatia.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
Sci Rep. 2025 Aug 28;15(1):31777. doi: 10.1038/s41598-025-17622-w.
A century of mining activities in the gold/arsenic mine of the Salsigne district (Southern France) has resulted in the contamination of water, soil, and wildlife with arsenic (As) as well as other metal(loid)s. The aim of this study was to detect As and 16 other metal(loid)s in non-invasive keratinized samples from companion dogs in the former mining area. In total, 49 hair samples (N = 22 from the control area in central France and N = 27 from the former Salsigne mining area) and 14 nails (N = 6 from the control area and N = 8 from the mining area) were collected from dogs. Analysis of covariance showed higher As levels in hair of dogs (p = 0.046) from the former mining area (mean ± SD 232 ± 382, median 86.8, range 17.8-1759 µg/kg dry mass) compared to those from the control area (70.9 ± 99.7, 48.3, 21.0-506 µg/kg), when sex, age, and body mass of animals were taken into account. Spatial differences in As levels in nails were not statistically confirmed although hair and nail As levels correlated significantly (r = 0.71, p = 0.004). Research has demonstrated that hair of companion dogs cohabiting humans reflect spatial differences among former mining and control groups and therefore can serve as early warning for exposure in the human population.
法国南部萨尔西涅区的金/砷矿长达一个世纪的采矿活动，导致水、土壤和野生动物受到砷（As）以及其他金属（类金属）的污染。本研究的目的是检测来自原矿区的伴侣犬非侵入性角质化样本中的砷和其他16种金属（类金属）。总共从犬只身上采集了49份毛发样本（法国中部对照区22份，原萨尔西涅矿区27份）和14份指甲样本（对照区6份，矿区8份）。协方差分析显示，在考虑动物的性别、年龄和体重后，原矿区犬只毛发中的砷含量（平均±标准差232±382，中位数86.8，范围17.8 - 1759微克/千克干质量）高于对照区犬只（70.9±99.7，48.3，21.0 - 506微克/千克）（p = 0.046）。尽管毛发和指甲中的砷含量显著相关（r = 0.71，p = 0.004），但指甲中砷含量的空间差异未得到统计学证实。研究表明，与人类共同生活的伴侣犬的毛发反映了原矿区和对照组之间的空间差异，因此可作为人类暴露的早期预警。
