Frederiks W M, Fronik G M, Marx F, James J
Liver. 1985 Dec;5(6):342-7. doi: 10.1111/j.1600-0676.1985.tb00257.x.
The influence of the nutritional state of rats on the volume of necrosis in the liver at 24 h after 60 min ischemia has been estimated using fresh liver slices incubated in tetranitro BT. The volume of necrosis is about 30% in an animal fed ad libitum and about 10% in rats fasted for 24 h. Standardization of the time of feeding using a food dispensing apparatus did not reduce the relatively high individual variation in the extent of liver cell necrosis after ischemia. The beneficial effect of fasting on the extent of liver cell necrosis induced by ischemia may be due to decreased acidosis and/or a change in metabolic status.
利用在四硝基蓝中孵育的新鲜肝切片，评估了大鼠营养状态对缺血60分钟后24小时肝脏坏死体积的影响。随意进食的动物坏死体积约为30%，禁食24小时的大鼠坏死体积约为10%。使用食物分配装置对喂食时间进行标准化，并未降低缺血后肝细胞坏死程度相对较高的个体差异。禁食对缺血诱导的肝细胞坏死程度的有益作用可能是由于酸中毒减轻和/或代谢状态改变。
