Morecraft R, Blair W F, Chang L
Microsurgery. 1985;6(4):219-28. doi: 10.1002/micr.1920060406.
The histopathology of microvascular repair was investigated in the femoral vein of the rat. Previous microvascular repair studies have primarily involved arteries, giving little insight to similar processes in veins. In our study, 36 rats with an average weight of 440 gm were randomly assigned to experimental groups of 1 hour, 24 hours, 2 weeks, and 4 weeks after repair. Histological evaluation of the suture site included the use of light, scanning electron, and transmission electron microscopy. Endothelial loss was observed in all 1-hour specimens. Extensive inflammatory response appeared in 2-hour specimens. Re-endothelialization of the intima was achieved in all animals by the 2-week time interval. At 4 weeks, the animals exhibited evidence of medial regeneration of smooth muscle cells. This was predominantly occurring between adjacent suture sites. Minimal subintimal hyperplasia was localized at the suture site itself in both 2- and 4-week specimens.
在大鼠股静脉中研究了微血管修复的组织病理学。以往的微血管修复研究主要涉及动脉，对静脉中的类似过程了解甚少。在我们的研究中，36只平均体重440克的大鼠被随机分配到修复后1小时、24小时、2周和4周的实验组。缝合部位的组织学评估包括使用光学显微镜、扫描电子显微镜和透射电子显微镜。在所有1小时的标本中均观察到内皮细胞丢失。在2小时的标本中出现了广泛的炎症反应。到2周时，所有动物的内膜均实现了重新内皮化。在4周时，动物表现出平滑肌细胞中层再生的迹象。这主要发生在相邻的缝合部位之间。在2周和4周的标本中，最小的内膜下增生局限于缝合部位本身。
