Bartels H L, van der Lei B, Robinson P H
Central Animal Laboratory, University of Groningen, The Netherlands.
Lab Anim. 1993 Jan;27(1):47-54. doi: 10.1258/002367793781082313.
Male Wistar rats were used to evaluate microvenous prosthetic grafting techniques and microvenous prostheses in the femoral vein. With the end-to-end technique to implant microvenous prostheses, there was extensive exposure of vessel wall collagen especially at the suture sites. Thrombus formation then led to complete occlusion in all but one of the 32 prostheses 60 min after implantation. However, with the sleeve anastomotic technique there was only minimal exposure of collagen and minimal thrombus accumulation. Fifty-nine of the 64 microvenous prostheses implanted with the sleeve technique were patent after 1 day, 1, 3, 6, and 12 weeks (patency rate 92%). All patent microvenous prostheses were completely covered by an endothelial layer after 3 weeks. It was concluded that the rat is an appropriate experimental laboratory animal for evaluating new grafting techniques with microvenous prostheses and that the sleeve anastomotic technique gives the highest patency rates with microvenous prostheses.
采用雄性Wistar大鼠评估股静脉的微静脉移植技术和微静脉假体。采用端端技术植入微静脉假体时，血管壁胶原广泛暴露，尤其是在缝合部位。血栓形成导致32个假体中除1个外，其余在植入60分钟后均完全闭塞。然而，采用套入式吻合技术时，胶原暴露极少，血栓积聚也极少。采用套入式技术植入的64个微静脉假体中，59个在1天、1周、3周、6周和12周后保持通畅（通畅率92%）。所有通畅的微静脉假体在3周后均完全被内皮细胞层覆盖。结论是，大鼠是评估微静脉假体新移植技术的合适实验动物，套入式吻合技术在微静脉假体中通畅率最高。
