Li Zhen, Chen Shuo-Xuan, Jiang Shuai, Yang Yi-Nong, Yan Xi-Chan
School of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan, China.
School of Rehabilitation Medicine and Health, Hunan University of Medicine, Huaihua, Hunan, China.
Front Pharmacol. 2025 Aug 13;16:1551452. doi: 10.3389/fphar.2025.1551452. eCollection 2025.
Metabolic reprogramming is the process by which cells adapt to different patterns of energy metabolism in response to the demands of the microenvironment for energy and biological macromolecules. Glucose serves as the primary energy source for cellular survival, and its metabolic pathways are intricately associated with cellular functional states. Recent studies have demonstrated that alterations in glucose metabolism, along with non-metabolic functions of metabolic enzymes and metabolites, play crucial roles in the development and progression of lung diseases under inflammatory conditions. This review summarizes the regulatory mechanisms of glucose metabolism across various pulmonary disorders and discusses the non-metabolic functions of glycolytic enzymes and metabolites in relation to disease pathogenesis. We aim to shine new light on the diagnosis and treatment of lung disease.
代谢重编程是细胞根据微环境对能量和生物大分子的需求，适应不同能量代谢模式的过程。葡萄糖是细胞生存的主要能量来源，其代谢途径与细胞功能状态密切相关。最近的研究表明，葡萄糖代谢的改变以及代谢酶和代谢产物的非代谢功能，在炎症条件下肺部疾病的发生和发展中起着关键作用。本综述总结了各种肺部疾病中葡萄糖代谢的调节机制，并讨论了糖酵解酶和代谢产物的非代谢功能与疾病发病机制的关系。我们旨在为肺部疾病的诊断和治疗提供新的思路。
