Maraki Sofia, Mavromanolaki Viktoria Eirini, Kasimati Anna
Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, 71500 Crete, Greece.
Department of Pediatrics, Agios Nikolaos General Hospital, Agios Nikolaos, 72100 Crete, Greece.
Maedica (Bucur). 2025 Jun;20(2):383-387. doi: 10.26574/maedica.2025.20.2.383.
Turicella otitidis is a Gram-positive bacillus, commensal inhabitant of the external auditory canal. It is the causative agent of external otitis and otitis media. Extra-otic infections are rarely been identified especially in patients with comorbidities. A narrative review was performed based on a search of PubMed/Medline and Scopus databases to collect information on the epidemiologic, clinical and microbiologic data of extra-otic infections by T. otitidis . Studies published until December 2024 were screened and analyzed to extract data on pathogen characteristics, antibiotic resistance profiles, treatment and outcomes. A total of 13 studies reporting infections by T. otitidis other than otitis including an equal number of patients were eligible. The mean age of patients was 34.08 years (range, 3-75 years). A male predominance was observed (1.6:1). Four patients were immunocompromised and four underwent recent surgical procedures. The most common infection type was bacteremia (38.4%), followed by abscesses, mastoiditis, ocular infections and skin and soft tissues infections. In the majority of cases (63.6%) a single method of identification was applied, such as matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS), polymerase chain reaction (PCR), Vitek 2 automated system and analytical profile index (API) Coryne. Antimicrobial resistance to erythromycin was 80%, while all isolates were susceptible to vancomycin. Vancomycin (45.5%) and cephalosporins (45.5%) were the most commonly used antimicrobials. In all cases with available data, the outcome was favorable. T. otitidis is an emerging pathogen causing extra-otic infections in humans, especially in the presence of predisposing conditions. Future studies are warranted to elucidate the microorganism's pathogenicity and the factors and mechanisms underlying its virulence.
耳道Turicella菌是一种革兰氏阳性杆菌，是外耳道的共生菌。它是外耳道炎和中耳炎的病原体。耳外感染很少被发现，尤其是在患有合并症的患者中。通过检索PubMed/Medline和Scopus数据库进行了一项叙述性综述，以收集有关耳道Turicella菌耳外感染的流行病学、临床和微生物学数据。筛选并分析了截至2024年12月发表的研究，以提取有关病原体特征、抗生素耐药性概况、治疗和结果的数据。共有13项报告耳道Turicella菌非耳部感染的研究符合条件，这些研究中的患者数量相等。患者的平均年龄为34.08岁（范围为3至75岁）。观察到男性占主导地位（1.6:1）。4名患者免疫功能低下，4名患者最近接受了外科手术。最常见的感染类型是菌血症（38.4%），其次是脓肿、乳突炎、眼部感染以及皮肤和软组织感染。在大多数病例（63.6%）中，采用了单一的鉴定方法，如基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）、聚合酶链反应（PCR）、Vitek 2自动化系统和Coryne分析谱指数（API）。对红霉素的API Coryne。对红霉素的耐药率为80%，而所有分离株对万古霉素敏感。万古霉素（45.5%）和头孢菌素（45.5%）是最常用的抗菌药物。在所有有可用数据的病例中，结果都是良好的。耳道Turicella菌是一种新兴病原体，可导致人类耳外感染，尤其是在存在易感条件的情况下。有必要进行进一步研究以阐明该微生物的致病性及其毒力的相关因素和机制。
