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光应激后的再适应时间。酒精诱导的急性及酒精后“宿醉”状态下眼部再适应时间的变化。

Readaptation time after photo stress. Alcohol-induced acute and post-alcohol 'hangover' changes in ocular readaptation time.

作者信息

Högman B, Bergman H, Borg S, Eriksson T, Goldberg L, Jones A W, Linde C J, Tengroth B

出版信息

Psychopharmacology (Berl). 1977 Jul 18;53(2):165-7. doi: 10.1007/BF00426487.

DOI:10.1007/BF00426487
PMID:408841
Abstract

The effect of alcohol intake on readaptation time (RAT) after photo stress is studied. Ten healthy subjects were given 0.72 g alcohol per kg body weight to be consumed within 20 min. The tests were made during a total period of 11-12 h. The findings demonstrate that moderate blood alcohol concentrations induce definite changes in RAT. An average RAT-prolongation of 60-70% was seen during the acute phase of intoxication. RAT-prolongation ended before the blood alcohol concentration had reached zero, but did not have the same downward slope. Following a period of reduction, a new prolongation of RAT was observed. The lack of congruence between the RAT-curve and the blood alcohol curve in the acute phase of intoxication and the post-alcohol increase are discussed. It is concluded that the alcohol-induced RAT-changes probably are CNS-effects and that the equipment used constitutes a sensitive method of estimating these effects.

摘要

研究了酒精摄入对光应激后再适应时间(RAT)的影响。给10名健康受试者每千克体重0.72克酒精,在20分钟内饮用。测试在总共11 - 12小时的时间段内进行。研究结果表明,适度的血液酒精浓度会引起RAT的明显变化。在急性中毒阶段,RAT平均延长60 - 70%。RAT延长在血液酒精浓度降至零之前结束,但下降斜率不同。经过一段时间的降低后,观察到RAT再次延长。讨论了急性中毒期RAT曲线与血液酒精曲线之间缺乏一致性以及酒精摄入后的增加情况。得出结论,酒精引起的RAT变化可能是中枢神经系统效应,并且所使用的设备构成了评估这些效应的灵敏方法。

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本文引用的文献

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Flicker-fusion in chronic barbiturate usage; a quantitative study in the pathophysiology of drug addiction.长期使用巴比妥酸盐时的闪光融合现象;药物成瘾病理生理学的定量研究
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Plasma concentrations and effects of methaqualone after single and multiple oral doses in man.甲喹酮单次及多次口服给药后在人体中的血浆浓度及效应
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Present and future trends in alcohol research.酒精研究的现状与未来趋势。
Br J Addict Alcohol Other Drugs. 1975 Apr;70 Suppl 1:3-11. doi: 10.1111/j.1360-0443.1975.tb01331.x.
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Readaptation time after photo stress. Readaptation time as a function of oxygen concentration.光应激后的再适应时间。再适应时间作为氧气浓度的函数。
Acta Ophthalmol (Copenh). 1976 Aug;54(4):507-16. doi: 10.1111/j.1755-3768.1976.tb01281.x.