Bergman H, Borg S, Högman B, Larsson H, Linde C J, Tengroth B
Acta Ophthalmol (Copenh). 1979 Feb;57(1):145-50. doi: 10.1111/j.1755-3768.1979.tb06668.x.
The readaptation time (RAT) is the interval during which a person exposed to a bright intense light flash cannot perceive a given target. In this study the target used was an optokinetic pattern and the elicited nystagmus (OKN) was registered with electrooculography (EOG), thus giving an objective registration of RAT. Oxazepam in therapeutic doses was given to five healthy subjects and the RAT and serum concentrations of the drug were registered simultaneously at different time intervals. An almost parallel increase of RAT and serum concentration of oxazepam was recorded. This suggests that RAT reflects the depressant effect on the CNS of this drug and it may be used as an objective method of following the clinical effect of a depressant drug as a function of time after intake.
重新适应时间（RAT）是指一个人在暴露于明亮强光闪烁后无法感知给定目标的时间间隔。在本研究中，所使用的目标是视动图案，并通过眼电图（EOG）记录诱发的眼球震颤（OKN），从而对RAT进行客观记录。给五名健康受试者服用治疗剂量的奥沙西泮，并在不同时间间隔同时记录RAT和药物的血清浓度。记录到奥沙西泮的RAT和血清浓度几乎呈平行增加。这表明RAT反映了该药物对中枢神经系统的抑制作用，并且它可以用作一种客观方法来跟踪摄入后随时间变化的抑制性药物的临床效果。
