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睡眠剥夺缺陷及其通过右旋和左旋苯丙胺的逆转。

Sleep deprivation deficits and their reversal by d- and l-amphetamine.

作者信息

Hartmann E, Orzack M H, Branconnier R

出版信息

Psychopharmacology (Berl). 1977 Jul 18;53(2):185-9. doi: 10.1007/BF00426490.

DOI:10.1007/BF00426490
PMID:408844
Abstract

Vigilance performance, waking EEG patterns and mood were studied before and after one night of sleep deprivation in normal males. The effects of d-amphetamine 10 mg, l-amphetamine 10 mg and placebo on these measures were compared. Changes were found in all three measures after one night of sleep-deprivation. d-Amphetamine was more powerful than l-amphetamine in reversing sleep deprivation effects on vigilance and on waking EEG.

摘要

对正常男性进行了一晚睡眠剥夺前后的警觉性表现、清醒脑电图模式和情绪研究。比较了10毫克右旋苯丙胺、10毫克左旋苯丙胺和安慰剂对这些指标的影响。经过一晚睡眠剥夺后,所有三项指标均出现变化。在逆转睡眠剥夺对警觉性和清醒脑电图的影响方面,右旋苯丙胺比左旋苯丙胺更有效。

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本文引用的文献

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The electroencephalogram during prolonged experimental sleep deprivation.长时间实验性睡眠剥夺期间的脑电图
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The effects of dextro-amphetamine on behavioral deficits produced by sleep loss in humans.右旋苯丙胺对人类睡眠剥夺所致行为缺陷的影响。
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Differential patterning of behavioral effects from three types of stimulant drugs.三种兴奋剂药物行为效应的差异模式
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Electroencephalogram and sleep deprivation.脑电图与睡眠剥夺
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The structure of mood: a comparison between sleep deprivation and normal wakefulness conditions.情绪的结构:睡眠剥夺与正常清醒状态的比较
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Amphetamine: differentiation by d and l isomers of behavior involving brain norepinephrine or dopamine.苯丙胺:通过涉及脑去甲肾上腺素或多巴胺的行为的d型和l型异构体进行区分。
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Differential effects of D- and L-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain.D-和L-苯丙胺对大鼠脑中含多巴胺和去甲肾上腺素神经元的行为及儿茶酚胺代谢的不同影响。
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Uptake of (3H)-catecholamines by homogenates of rat corpus striatum and cerebral cortex: effects of amphetamine analogues.大鼠纹状体和大脑皮质匀浆对(3H)-儿茶酚胺的摄取:苯丙胺类似物的影响。
Neuropharmacology. 1973 Jul;12(7):669-79. doi: 10.1016/0028-3908(73)90120-2.