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纹状体单侧儿茶酚胺耗竭与苯丙胺诱导的旋转：一项个体发生学研究。

Unilateral catecholamine depletion of the corpus striatum and amphetamine-induced turning: an ontogenetic study.

作者信息

White B C, Tapp W N

出版信息

Psychopharmacology (Berl). 1977 Jul 18;53(2):211-2. doi: 10.1007/BF00426496.

DOI:10.1007/BF00426496
PMID:408848
Abstract

Unilateral intrastriatal microinjections of alpha-methyl-p-tyrosine followed by systemic amphetamine treatment produced turning ipsilateral to the side of the injection in rats from 12 days of age to maturity, but not in rats younger than 12 days. These results are consistent with other findings that indicate rapid development of the striatal dopaminergic system and dopaminergic component of the amphetamine stereotypy in the second postnatal week.

摘要

对12日龄至成年大鼠进行单侧纹状体内微量注射α-甲基对酪氨酸，随后进行全身性苯丙胺治疗，大鼠会向注射侧的同侧旋转，但12日龄以下的大鼠不会。这些结果与其他研究结果一致，这些研究结果表明，在出生后的第二周，纹状体多巴胺能系统和苯丙胺刻板行为的多巴胺能成分迅速发育。

相似文献

1
Unilateral catecholamine depletion of the corpus striatum and amphetamine-induced turning: an ontogenetic study.纹状体单侧儿茶酚胺耗竭与苯丙胺诱导的旋转：一项个体发生学研究。
Psychopharmacology (Berl). 1977 Jul 18;53(2):211-2. doi: 10.1007/BF00426496.
2
Ascorbate blocks amphetamine-induced turning behavior in rats with unilateral nigro-striatal lesions.抗坏血酸盐可阻断单侧黑质纹状体损伤大鼠中苯丙胺诱导的旋转行为。
Brain Res Bull. 1979 Jan-Feb;4(1):43-8. doi: 10.1016/0361-9230(79)90056-x.
3
The effect of drugs altering striatal dopamine levels on apomorphine induced stereotypy.改变纹状体多巴胺水平的药物对阿扑吗啡诱导的刻板行为的影响。
Pharmacol Biochem Behav. 1982 Feb;16(2):235-40. doi: 10.1016/0091-3057(82)90154-x.
4
The effects of narcotic analgesics on the turning behaviour of rats with 6-hydroxydopamine-induced unilateral nigro-striatal lesions.麻醉性镇痛药对6-羟基多巴胺诱导的单侧黑质-纹状体损伤大鼠旋转行为的影响。
Neuropharmacology. 1980 Feb;19(2):187-93. doi: 10.1016/0028-3908(80)90137-9.
5
Amphetamine-induced locomotor activity and stereotypy after kainic acid lesions of the striatum.纹状体经海人酸损伤后苯丙胺诱导的运动活性和刻板行为。
Life Sci. 1978 Feb;22(6):451-9. doi: 10.1016/0024-3205(78)90424-1.
6
Spontaneous and amphetamine-induced behavior after bilateral injection of ethanolamine-O-sulfate into the substantia nigra.双侧向黑质注射乙醇胺 - O - 硫酸盐后的自发行为和苯丙胺诱导行为。
Brain Res. 1978 May 12;146(2):313-23. doi: 10.1016/0006-8993(78)90976-9.
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Amphetamine behavioral toxicity: rotational behavior after chronic intrastriatal infusion.苯丙胺行为毒性：慢性纹状体内注射后的旋转行为
Biol Psychiatry. 1981 May;16(5):479-88.
8
A two-population model of rat rotational behavior: effects of unilateral nigrostriatal 6-hydroxydopamine on striatal neurochemistry and amphetamine-induced rotation.大鼠旋转行为的双群体模型：单侧黑质纹状体6-羟基多巴胺对纹状体神经化学及苯丙胺诱导旋转的影响
Brain Res. 1987 Nov 24;426(2):323-31. doi: 10.1016/0006-8993(87)90885-7.
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Circling behavior following systemic d-amphetamine administration: potential noradrenergic and dopaminergic involvement.全身给予右旋苯丙胺后的转圈行为：潜在的去甲肾上腺素能和多巴胺能参与。
Psychopharmacology (Berl). 1979 Jun 28;64(1):45-54. doi: 10.1007/BF00427344.
10
The role of D1 and D2 dopamine receptors in oral stereotypy induced by dopaminergic stimulation of the ventrolateral striatum.D1和D2多巴胺受体在腹外侧纹状体多巴胺能刺激诱导的口腔刻板行为中的作用。
Neuroscience. 1990;39(1):59-67. doi: 10.1016/0306-4522(90)90221-o.

引用本文的文献

1
Enduring behavioural and biochemical effects in the adult rat after prolonged postnatal administration of haloperidol.
Psychopharmacology (Berl). 1981;74(2):166-9. doi: 10.1007/BF00432686.

本文引用的文献

1
Stereotype hyperactive behaviour produced by dopamine in the absence of noradrenaline.在去甲肾上腺素缺乏的情况下，多巴胺产生的刻板多动行为。
Life Sci. 1967 Jul 1;6(13):1389-98. doi: 10.1016/0024-3205(67)90186-5.
2
Ontogeny of stereotyped behaviour induced by apomorphine and amphetamine in the rat.
Arch Int Pharmacodyn Ther. 1973 Mar;202(1):171-82.
3
Regional development of catecholamine biosynthesis in rat brain.大鼠脑中儿茶酚胺生物合成的区域发育。
J Neurochem. 1972 Aug;19(8):1917-30. doi: 10.1111/j.1471-4159.1972.tb01480.x.
4
Tyrosine hydroxylase in rat brain: developmental characteristics.大鼠脑中的酪氨酸羟化酶：发育特征
J Neurochem. 1972 Apr;19(4):1117-23. doi: 10.1111/j.1471-4159.1972.tb01431.x.
5
Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.通过旋转行为揭示的苯丙胺或神经变性后的纹状体多巴胺释放。
Acta Physiol Scand Suppl. 1971;367:49-68. doi: 10.1111/j.1365-201x.1971.tb10999.x.
6
In vivo continuous estimation of 3 H-dopamine synthesis and release in the cat caudate nucleus. Effects of -methyl-p-tyrosine and of transection of the nigro neostriatal pathway.猫尾状核中³H-多巴胺合成与释放的体内连续评估。α-甲基对酪氨酸和黑质-新纹状体通路横断的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1973;278(1):101-5. doi: 10.1007/BF00501867.
7
The role of monoamines in rotation induced or potentiated by amphetamine after nigral, raphe and mesencephalic reticular lesions in the rat brain.单胺在大鼠脑黑质、中缝和中脑网状结构损伤后由苯丙胺诱导或增强的旋转中的作用。
Neuropharmacology. 1973 Mar;12(3):195-211. doi: 10.1016/0028-3908(73)90104-4.
8
Postnatal development of locomotion in the laboratory rat.实验大鼠运动的产后发育
Anim Behav. 1975 Nov;23(4):896-920. doi: 10.1016/0003-3472(75)90114-1.