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小鼠对d-苯丙胺行为反应的遗传分析。

Genetic analysis of the behavioral response to d-amphetamine in mice.

作者信息

Moisset B

出版信息

Psychopharmacology (Berl). 1977 Aug 16;53(3):263-7.

PMID:408855
Abstract

The ambulatory and rearing responses to d-amphetamine were studied in a battery of recombinant inbred strains and in three closely related strains: C57BL/6J, C57Bl/10J, and C57BL/LBy. Differences in the increase of ambulation (stimulation) caused by d-amphetamine were seen between C57BL/6By and the other two C57BL strains. Analysis of F1 and backcross matings suggests a one-gene model. A mutation at the genetic locus that affects the response to d-amphetamine seems to have taken place in the C5BL/6By strain. Strain differences in the decrease of rearing behavior (inhibition) produced by the drug were observed in recombinant inbred strains. Although th of l-dihydroxyphenylalanine (L-dopa) and d,l,5-hydroxytryptophan (d,l,5-HTP) on reserpine-induced amnesia.

摘要

在一系列重组近交系以及三个密切相关的品系

C57BL/6J、C57Bl/10J和C57BL/LBy中，研究了对d-苯丙胺的自主活动和竖毛反应。在C57BL/6By与其他两个C57BL品系之间，观察到了由d-苯丙胺引起的自主活动增加（刺激）的差异。对F1和回交交配的分析表明存在单基因模型。在C5BL/6By品系中，似乎发生了影响对d-苯丙胺反应的基因座突变。在重组近交系中观察到了该药物引起的竖毛行为减少（抑制）的品系差异。尽管左旋多巴（L-dopa）和消旋5-羟色氨酸（d，l，5-HTP）对利血平诱导的失忆有影响。

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本文引用的文献

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EFFECT OF DRUGS ON THE UPTAKE, RELEASE, AND METABOLISM OF H3-NOREPINEPHRINE IN THE RAT BRAIN.药物对大鼠脑中H3-去甲肾上腺素摄取、释放及代谢的影响
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Amphetamine induced selective stimulation of certain behaviour items with concurrent inhibition of others in an open-field test with rats.在对大鼠的旷场试验中，苯丙胺引起对某些行为项目的选择性刺激，同时抑制其他行为项目。
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Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.
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Strain differences in amphetamine sensitivity in mice. II. Overcompensation of paradoxical sleep after deprivation in two C57 strains.小鼠对苯丙胺敏感性的品系差异。II. 两种C57品系剥夺后异相睡眠的过度补偿
Psychopharmacology (Berl). 1979;66(3):291-5. doi: 10.1007/BF00428322.
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Psychopharmacology (Berl). 1979 Nov;66(2):189-94. doi: 10.1007/BF00427629.
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