Weiss B, Santelli S, Lusink G
Psychopharmacology (Berl). 1977 Aug 16;53(3):289-93. doi: 10.1007/BF00492366.
After several months of treatment, Cebus apella, Cebus albifrons, and Saimiri sciurea monkeys maintained on haloperidol, in doses of 0.5 or 1.0 mg/kg orally 5 days per week, began to display severe movement disorders, typically 1-6 h post-drug. Cebus monkeys exhibited violent, uncontrolled movements that flung the animals about the cage. Such episodes usually lasted only a few minutes, recurring several times during the period following drug ingestion. Writhing and bizarre postures dominated the response in S. sciurea. Cessation of drug treatment produced no distinctive after-effects. When tested as long as 508 days after the last administration, however, Cebus monkeys responded to haloperidol with several episodes of hyperkinesis, even at challenge doses considerably lower than those in the original treatment.
经过数月治疗后，每周5天口服剂量为0.5或1.0毫克/千克氟哌啶醇的卷尾猴、白额卷尾猴和松鼠猴开始出现严重的运动障碍，通常在用药后1 - 6小时出现。卷尾猴表现出剧烈的、不受控制的运动，将动物甩到笼子各处。此类发作通常仅持续几分钟，在服药后的一段时间内会反复出现几次。扭体和怪异姿势在松鼠猴的反应中占主导。停止药物治疗未产生明显的后遗症。然而，在最后一次给药长达508天后进行测试时，即使挑战剂量远低于最初治疗时的剂量，卷尾猴对氟哌啶醇仍会出现几次运动亢进发作。
