前列腺素生物合成抑制剂与表皮损伤
Inhibitor(s) of prostaglandin biosynthesis and epidermal injury.
作者信息
Penneys N S, Lord J T, Ziboh V A, Simon P
出版信息
Prostaglandins. 1977 Aug;14(2):355-62. doi: 10.1016/0090-6980(77)90180-0.
PMID:408878
Abstract
Inhibition of the activity of sheep vesicular gland prostaglandin synthetase (a rare limiting enzyme in the biosynthesis of prostaglandins) was demonstrated in the presence of homogenates prepared from skin lesions characterized histologically by epidermal disruption. These inhibitory effects were not observed in homogenates of skin lesions characterized by a lack of epidermal disruption.
摘要
在由组织学特征为表皮破坏的皮肤损伤制备的匀浆存在的情况下，证实了绵羊精囊前列腺素合成酶（前列腺素生物合成中一种罕见的限速酶）的活性受到抑制。在组织学特征为缺乏表皮破坏的皮肤损伤匀浆中未观察到这些抑制作用。
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