通过类三链体相互作用识别腺嘌呤衍生物的高亲和力二聚体尿嘧啶基受体。
High Affinity Dimeric Uracil-Based Receptor for the Recognition of Adenine Derivatives through Triplex-like Interactions.
作者信息
Volpi Stefano, Rivi Nicola, Korom Saša, Neri Martina, Knoll Wolfgang, Corradini Roberto
机构信息
Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17 A, 43124 Parma, Italy.
Istituto Nazionale Biostrutture e Biosistemi, INBB, Via dei Carpegna 19, 00165Roma, Italy.
出版信息
J Org Chem. 2025 Sep 12;90(36):12814-12819. doi: 10.1021/acs.joc.5c01309. Epub 2025 Sep 1.
Adenine recognition through triplex-like interactions was explored using clamp-shaped artificial receptor , bearing two uracil units and an extended naphthalene scaffold. The requisite binding mode was confirmed for 9-ethyladenine in CDCl via NMR investigations. Phase-transfer experiments demonstrated that selectively binds adenosine from an aqueous mixture of four ribonucleosides.
使用带有两个尿嘧啶单元和一个扩展萘支架的钳形人工受体，通过类三链体相互作用探索了腺嘌呤识别。通过核磁共振研究在CDCl中确认了9-乙基腺嘌呤的必要结合模式。相转移实验表明，其能从四种核糖核苷的水性混合物中选择性结合腺苷。
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