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"Good" fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis.

作者信息

Choi Dong Wook, Lee Eun-Woo

机构信息

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.

Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.

出版信息

Signal Transduct Target Ther. 2025 Sep 2;10(1):284. doi: 10.1038/s41392-025-02373-x.

DOI:10.1038/s41392-025-02373-x
PMID:40890110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12402223/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c42/12402223/073a1f53ac46/41392_2025_2373_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c42/12402223/073a1f53ac46/41392_2025_2373_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c42/12402223/073a1f53ac46/41392_2025_2373_Fig1_HTML.jpg

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本文引用的文献

1
Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis.糖胺聚糖驱动的脂蛋白摄取可保护肿瘤免受铁死亡。
Nature. 2025 Jun 11. doi: 10.1038/s41586-025-09162-0.
2
Recommendations for robust and reproducible research on ferroptosis.关于铁死亡的稳健且可重复研究的建议。
Nat Rev Mol Cell Biol. 2025 Apr 9. doi: 10.1038/s41580-025-00843-2.
3
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis.通过脂质组学分析重新审视铁死亡中脂质代谢的综合观点。
Exp Mol Med. 2023 Aug;55(8):1620-1631. doi: 10.1038/s12276-023-01077-y. Epub 2023 Aug 23.
4
Understanding the tumor immune microenvironment (TIME) for effective therapy.理解肿瘤免疫微环境(TIME)以实现有效的治疗。
Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23.
5
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).维生素 E 与前列腺癌风险:硒和维生素 E 癌症预防试验(SELECT)。
JAMA. 2011 Oct 12;306(14):1549-56. doi: 10.1001/jama.2011.1437.