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Esketamine alleviates depressive-like behavior in mice via modulation of the microbiota-gut-brain axis and amino acid metabolism.

作者信息

Gong Xue, Lai ZengYan, Li Lei, Fan Li, Ren Yikun, Zhong Qi, Mao Qiang

机构信息

Department of Neurology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, China.

Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

出版信息

BMC Microbiol. 2025 Sep 1;25(1):570. doi: 10.1186/s12866-025-04181-3.


DOI:10.1186/s12866-025-04181-3
PMID:40890568
Abstract
摘要

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[1]
Esketamine alleviates depressive-like behavior in mice via modulation of the microbiota-gut-brain axis and amino acid metabolism.

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本文引用的文献

[1]
Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents.

Microbiome. 2025-5-19

[2]
Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus.

Prog Neurobiol. 2025-3

[3]
Editorial: Gut microbiota and immunity in health and disease: dysbiosis and eubiosis's effects on the human body.

Front Immunol. 2024-12-17

[4]
Gut microbiota in health and disease: advances and future prospects.

MedComm (2020). 2024-11-20

[5]
Quantification of Glutathione and Its Associated Spontaneous Neuronal Activity in Major Depressive Disorder and Obsessive-Compulsive Disorder.

Biol Psychiatry. 2025-2-1

[6]
Advancing past ketamine: emerging glutamatergic compounds for the treatment of depression.

Eur Arch Psychiatry Clin Neurosci. 2024-8-29

[7]
CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function.

Mol Neurobiol. 2025-2

[8]
Majorbio Cloud 2024: Update single-cell and multiomics workflows.

Imeta. 2024-6-25

[9]
Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review.

Front Neurosci. 2024-6-3

[10]
Current treatment options for leptospirosis: a mini-review.

Front Microbiol. 2024-4-25

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