Petakh Pavlo, Duve Khrystyna, Oksenych Valentyn, Behzadi Payam, Kamyshnyi Oleksandr
Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine.
Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Front Neurosci. 2024 Jun 3;18:1394953. doi: 10.3389/fnins.2024.1394953. eCollection 2024.
This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting the microbiota-gut-brain axis, this study investigated the bidirectional communication between the gut microbiome and mental health. SCFAs, byproducts of gut microbial fermentation, have been examined for their potential impact on PTSD, with a focus on molecular mechanisms and therapeutic interventions. This review discusses changes in SCFA levels and bacterial profiles in individuals with PTSD, emphasizing the need for further research. Promising outcomes from clinical trials using probiotics and fermented formulations suggest potential avenues for PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, and employing advanced computational methods, with the goal of deepening our understanding of the role of SCFAs in PTSD and exploring microbiota-targeted interventions.
本综述探讨了短链脂肪酸（SCFAs）在创伤后应激障碍（PTSD）中的作用。本研究以微生物群-肠-脑轴为重点，调查了肠道微生物群与心理健康之间的双向交流。作为肠道微生物发酵的副产物，短链脂肪酸已被研究其对创伤后应激障碍的潜在影响，重点关注分子机制和治疗干预措施。本综述讨论了创伤后应激障碍患者短链脂肪酸水平和细菌谱的变化，强调了进一步研究的必要性。使用益生菌和发酵制剂的临床试验取得的有希望的结果表明了创伤后应激障碍管理的潜在途径。未来的方向包括建立全面的人类队列、整合多组学数据以及采用先进的计算方法，目标是加深我们对短链脂肪酸在创伤后应激障碍中的作用的理解，并探索以微生物群为靶点的干预措施。
