Lin Guisen, Tan Weiting, Zhang Shaojun, Yang Qin, Zhuang Yijiang, Hu Shijie, Mo Dongxia, Deng Kan, Ye Wenhong, Zeng Hongwu
Department of Radiology, Shenzhen Children's Hospital, Shenzhen, China.
Department of Medical Imaging, Shenzhen Luohu People's Hospital, Shenzhen, China.
Brain Behav. 2025 Sep;15(9):e70808. doi: 10.1002/brb3.70808.
To investigate alteration of brain amide proton transfer weighted (APTw) signals in children with obstructive sleep apnea (OSA) and to assess the association of APTw signals in different brain regions with cognitive impairment.
This prospective study was conducted from September 2021 to December 2023. Forty-six children with mild to severe OSA and 20 non-OSA volunteers with matched age and gender underwent a whole brain APTw imaging scan. The APTw signals of 29 regions of the brain were compared between the OSA group and volunteers with Fisher's least significant differences post-hoc analysis or the Kruskal-Wallis test with the Steel-Dwass test. The correlation of the APTw signals of different brain regions and cognitive assessment scores was analyzed with Pearson's correlation analysis or Spearman's correlation analysis.
The APTw signals in the white matter of the inferior frontal gyrus, the white matter of the angular gyrus, and the thalamus of children with mild OSA and volunteers were significantly lower than that of children with moderate-severe OSA. The APTw signals of the gray matter of the supramarginal gyrus, the gray matter of the lingual gyrus, the corona radiata, and the genu of corpus callosum in children with moderate-severe OSA were significantly lower than that of volunteers. The APTw signals of the frontal-parietal-temporal regions, hippocampus, and corona radiata were significantly associated with cognitive assessment scores.
APTw imaging could be used for detecting frontal-parietal-temporal regions and hippocampus damage in children with OSA, which possibly explain cognitive impairments associated with OSA.
探讨阻塞性睡眠呼吸暂停（OSA）患儿脑酰胺质子转移加权（APTw）信号的变化，并评估不同脑区APTw信号与认知障碍的相关性。
本前瞻性研究于2021年9月至2023年12月进行。46例轻至重度OSA患儿和20例年龄、性别匹配的非OSA志愿者接受了全脑APTw成像扫描。采用Fisher最小显著差异事后分析或Kruskal-Wallis检验及Steel-Dwass检验比较OSA组和志愿者之间29个脑区的APTw信号。采用Pearson相关分析或Spearman相关分析分析不同脑区APTw信号与认知评估分数的相关性。
轻度OSA患儿和志愿者的额下回白质、角回白质和丘脑的APTw信号显著低于中度至重度OSA患儿。中度至重度OSA患儿的缘上回灰质、舌回灰质、放射冠和胼胝体膝部的APTw信号显著低于志愿者。额颞顶叶区域、海马体和放射冠的APTw信号与认知评估分数显著相关。
APTw成像可用于检测OSA患儿的额颞顶叶区域和海马体损伤，这可能解释了与OSA相关的认知障碍。
