Larrañaga A, Sartoretto J N, Winterhalter M, Navas Filho F
Int J Fertil. 1978;23(3):193-9.
Four hundred and fifty-eight women were followed for 3,586 cycles in a controlled, randomized, open trial designed to compare two biphasic and one triphasic norgestrel/ethinyl estradiol (ee) regimens. The three regimens are effective and no pregnancies were reported. Cycle control was good with all three regimens but the incidence of intermenstrual bleeding was higher with the triphasic. With this regimen, total hormonal ingestion is well below the lowest fixed dose norgestrel/ethinyl estradiol preparation (300 mcg norgestrel and 30 mcg ee) in the original 10:1 ratio. It is concluded that the staggering of hormonal doses opens the possibility of contraception with less hormone intake than is possible when a fixed dose regimen is used.
在一项对照、随机、开放试验中，对458名女性进行了3586个周期的跟踪，该试验旨在比较两种双相和一种三相炔诺孕酮/炔雌醇（ee）方案。这三种方案均有效，且未报告妊娠情况。所有三种方案的周期控制都良好，但三相方案的经间期出血发生率较高。使用该方案时，总激素摄入量远低于最初10:1比例的最低固定剂量炔诺孕酮/炔雌醇制剂（300微克炔诺孕酮和30微克ee）。结论是，激素剂量的错开使得以比使用固定剂量方案时更少的激素摄入量进行避孕成为可能。
