• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

引发颌骨空洞性骨坏死的神经痛:科学争议还是伪科学?

Neuralgia Inducing Cavitational Osteonecrosis of the Jaw: Scientific Controversy or pseudoscience?

作者信息

Keith David A

机构信息

Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Visiting Oral and Maxillofacial Surgeon, Massachusetts General Hospital, Boston, MA, USA.

出版信息

J Pain Res. 2025 Aug 24;18:4275-4284. doi: 10.2147/JPR.S533032. eCollection 2025.

DOI:10.2147/JPR.S533032
PMID:40893123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12393081/
Abstract

Jawbone cavities have had a long history in dentistry and for many years they have been described and studied under several different pseudonyms. These cavities are thought to be responsible for a wide range of disease processes and symptoms, including orofacial neuralgia. In this article the existence of jawbone cavities, and their role in the etiology of orofacial pain will be critically examined. The validity and significance of these cavities has been questioned in the literature and found to lack sufficient scientific validation, posing potential harm to patients. Treatments based on this diagnosis have been the subject of legal action brought by patients, by a Medical Insurance Company, which has claimed insurance fraud and by several professional organizations. Ethical, regulatory and financial issues have also been raised. Evidence based diagnostic criteria and clinical trials are needed to determine the scientific validity of this concept. Pain in the mouth and face is best diagnosed using current evidence based diagnostic criteria.

摘要

颌骨空洞在牙科领域有着悠久的历史,多年来它们一直以几种不同的别名被描述和研究。这些空洞被认为与多种疾病过程和症状有关,包括口面部神经痛。在本文中,将对颌骨空洞的存在及其在口面部疼痛病因学中的作用进行批判性审视。这些空洞的有效性和重要性在文献中受到质疑,并且被发现缺乏充分的科学验证,这对患者构成了潜在危害。基于这种诊断的治疗方法已成为患者、一家声称存在保险欺诈的医疗保险公司以及几个专业组织提起法律诉讼的对象。同时也引发了伦理、监管和财务问题。需要基于证据的诊断标准和临床试验来确定这一概念的科学有效性。口腔和面部疼痛最好使用当前基于证据的诊断标准进行诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75f8/12393081/a619f10138a7/JPR-18-4275-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75f8/12393081/a619f10138a7/JPR-18-4275-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75f8/12393081/a619f10138a7/JPR-18-4275-g0001.jpg

相似文献

1
Neuralgia Inducing Cavitational Osteonecrosis of the Jaw: Scientific Controversy or pseudoscience?引发颌骨空洞性骨坏死的神经痛:科学争议还是伪科学?
J Pain Res. 2025 Aug 24;18:4275-4284. doi: 10.2147/JPR.S533032. eCollection 2025.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方:益处与风险
3
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
4
Anterior Approach Total Ankle Arthroplasty with Patient-Specific Cut Guides.使用患者特异性截骨导向器的前路全踝关节置换术。
JBJS Essent Surg Tech. 2025 Aug 15;15(3). doi: 10.2106/JBJS.ST.23.00027. eCollection 2025 Jul-Sep.
5
A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer.对紫杉醇、多西他赛、吉西他滨和长春瑞滨在非小细胞肺癌中的临床疗效和成本效益进行的快速系统评价。
Health Technol Assess. 2001;5(32):1-195. doi: 10.3310/hta5320.
6
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中,如果患者出现以下症状和体征,可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.
7
Assessing the comparative effects of interventions in COPD: a tutorial on network meta-analysis for clinicians.评估慢性阻塞性肺疾病干预措施的比较效果:面向临床医生的网状Meta分析教程
Respir Res. 2024 Dec 21;25(1):438. doi: 10.1186/s12931-024-03056-x.
8
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病:网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
9
Sexual Harassment and Prevention Training性骚扰与预防培训
10
Diagnosis and management of dental caries throughout life.一生当中龋齿的诊断与管理。
NIH Consens Statement. 2001;18(1):1-23.

本文引用的文献

1
Fatty Degenerative Osteonecrosis of the Jaw: Bridging Molecular Insights and Clinical Practice-A Scoping Review.颌骨脂肪性变性骨坏死:连接分子见解与临床实践——一项范围综述
Int J Mol Sci. 2025 Feb 21;26(5):1853. doi: 10.3390/ijms26051853.
2
Creating patients: how technology and measurement approaches are misused in diagnosis and convert healthy individuals into TMD patients.制造患者:技术和测量方法在诊断中是如何被滥用并将健康个体转变为颞下颌关节紊乱病患者的。
Front Dent Med. 2023 Oct 12;4:1183327. doi: 10.3389/fdmed.2023.1183327. eCollection 2023.
3
Dental Ultrasonography for Visualizing Osteoimmune Conditions and Assessing Jaw Bone Density: A Narrative Review.
用于可视化骨免疫状况和评估颌骨密度的牙科超声检查:一项叙述性综述。
Med Devices (Auckl). 2025 Jan 7;18:1-13. doi: 10.2147/MDER.S491331. eCollection 2025.
4
The Lyceum for Pain Education: Providing Accessible Education on Chronic Pain and Headaches to a Global Audience.疼痛教育学园:为全球受众提供关于慢性疼痛和头痛的普及教育。
J Pain Res. 2024 Apr 13;17:1503-1507. doi: 10.2147/JPR.S470973. eCollection 2024.
5
Re: Reduction of Inflammatory RANTES/CCLS Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone [Response to Letter].回复:手术降低颌骨骨髓缺损患者血清中炎症趋化因子RANTES/CCL水平[对信件的回复]
Clin Cosmet Investig Dent. 2023 Nov 9;15:301-302. doi: 10.2147/CCIDE.S447266. eCollection 2023.
6
Re: Reduction of Inflammatory RANTES/CCLS Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone [Letter].回复:手术降低颌骨骨髓缺损患者血清中炎性趋化因子RANTES/CCL水平[信件]
Clin Cosmet Investig Dent. 2023 Nov 1;15:279-280. doi: 10.2147/CCIDE.S443950. eCollection 2023.
7
Reduction of Inflammatory RANTES/CCL5 Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone.手术降低颌骨骨髓缺损患者血清中炎症趋化因子RANTES/CCL5水平
Clin Cosmet Investig Dent. 2023 Sep 8;15:181-188. doi: 10.2147/CCIDE.S417783. eCollection 2023.
8
A historical review of 'phossy jaw'.“磷毒性颌骨坏死”的历史回顾。
Br Dent J. 2023 Jun;234(11):825-826. doi: 10.1038/s41415-023-5859-9. Epub 2023 Jun 9.
9
Practical Guide to Designing a Clinical Trial in Surgery.外科临床试验设计实用指南
JAMA Surg. 2022 Dec 1;157(12):1152-1153. doi: 10.1001/jamasurg.2022.4883.
10
Challenging NICO again?又在挑战尼科(NICO)了?
Oral Dis. 2023 May;29(4):1885-1886. doi: 10.1111/odi.14041. Epub 2021 Oct 21.