Göke B, Göke R, Lankisch P G
Res Exp Med (Berl). 1985;185(6):503-7. doi: 10.1007/BF01851856.
The effect of the epsilon-guanidino acid derivate camostate (FOY 305) on lipolysis of isolated adipocytes was evaluated to test its supposed influence on the reactions of lipid metabolism in experimental shock. Isoprenaline (10(-6) M) and theophylline (10(-3) M) significantly stimulated lipolysis in vitro. The basal submaximal (isoprenaline 10(-6)-10(-9) M) and maximal (isoprenaline 10(-6) M) catecholamine-stimulated lipolysis were not affected by camostate (10(-6) M). Furthermore, camostate (0.1-100 X 10(-6) M) did not influence half-maximal theophylline-induced lipolysis of the adipocytes. Our findings do not support the suggestion that epsilon-guanidino acid derivatives diminish in shock the increase of free fatty acids in blood via an influence on lipolysis in the peripheral adipose tissue.
评估了ε-胍基酸衍生物卡莫司他（FOY 305）对分离的脂肪细胞脂解作用的影响，以测试其对实验性休克中脂质代谢反应的假定影响。异丙肾上腺素（10⁻⁶ M）和茶碱（10⁻³ M）在体外显著刺激脂解。卡莫司他（10⁻⁶ M）不影响基础次最大（异丙肾上腺素10⁻⁶ - 10⁻⁹ M）和最大（异丙肾上腺素10⁻⁶ M）儿茶酚胺刺激的脂解。此外，卡莫司他（0.1 - 100×10⁻⁶ M）不影响茶碱诱导的脂肪细胞半最大脂解。我们的研究结果不支持ε-胍基酸衍生物在休克中通过影响外周脂肪组织的脂解作用来减少血液中游离脂肪酸增加的观点。
