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New perspectives in biology-driven treatment of cholangiocarcinoma: from oncological resectability to genetic breakthroughs and AI-powered imaging.

作者信息

Viganò Luca, Risi Luca, Ammirabile Angela

机构信息

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Hepatobiliary Unit, Department of Minimally Invasive General & Oncologic Surgery, Humanitas Gavazzeni University Hospital, Bergamo, Italy.

出版信息

Hepatobiliary Surg Nutr. 2025 Aug 1;14(4):703-708. doi: 10.21037/hbsn-2025-261. Epub 2025 Jul 22.

DOI:10.21037/hbsn-2025-261
PMID:40893768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12393095/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badc/12393095/1fac10520ee7/hbsn-14-04-703-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badc/12393095/1fac10520ee7/hbsn-14-04-703-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badc/12393095/1fac10520ee7/hbsn-14-04-703-f1.jpg

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本文引用的文献

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Genetic predictors of postoperative recurrence in node-negative intrahepatic cholangiocarcinoma.淋巴结阴性肝内胆管癌术后复发的基因预测指标
Updates Surg. 2025 Apr 2. doi: 10.1007/s13304-025-02189-y.
2
Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma.空间单细胞蛋白质组学全景解析肝内胆管癌的肿瘤微环境生态系统。
Hepatology. 2025 Feb 25. doi: 10.1097/HEP.0000000000001283.
3
Radiogenomics of intrahepatic cholangiocarcinoma predicts immunochemotherapy response and identifies therapeutic target.
肝内胆管癌的放射基因组学可预测免疫化疗反应并确定治疗靶点。
Clin Mol Hepatol. 2025 Jul;31(3):935-959. doi: 10.3350/cmh.2024.0895. Epub 2025 Feb 10.
4
Habitat radiomics based on CT images to predict survival and immune status in hepatocellular carcinoma, a multi-cohort validation study.基于CT图像的肝脏影像组学预测肝细胞癌的生存及免疫状态：一项多队列验证研究
Transl Oncol. 2025 Feb;52:102260. doi: 10.1016/j.tranon.2024.102260. Epub 2025 Jan 2.
5
Neoadjuvant therapy reduces node positivity but does not confer survival benefit versus up-front resection for resectable intrahepatic cholangiocarcinoma: A propensity-matched analysis.新辅助治疗可降低可切除性肝内胆管细胞癌的淋巴结阳性率，但与直接切除相比并不能带来生存获益：一项倾向评分匹配分析。
J Surg Oncol. 2024 Sep;130(3):453-461. doi: 10.1002/jso.27743. Epub 2024 Jul 31.
6
CT-based radiogenomics of intrahepatic cholangiocarcinoma.
Dig Liver Dis. 2025 Jan;57(1):118-124. doi: 10.1016/j.dld.2024.06.033. Epub 2024 Jul 12.
7
FGFR2 fusion/rearrangement is associated with favorable prognosis and immunoactivation in patients with intrahepatic cholangiocarcinoma.FGFR2融合/重排在肝内胆管癌患者中与良好预后及免疫激活相关。
Oncologist. 2024 Dec 6;29(12):e1734-e1747. doi: 10.1093/oncolo/oyae170.
8
Radiomics of Intrahepatic Cholangiocarcinoma and Peritumoral Tissue Predicts Postoperative Survival: Development of a CT-Based Clinical-Radiomic Model.肝内胆管癌及瘤周组织的影像组学预测术后生存：基于CT的临床影像组学模型的建立
Ann Surg Oncol. 2024 Sep;31(9):5604-5614. doi: 10.1245/s10434-024-15457-9. Epub 2024 May 26.
9
Neoadjuvant therapy leads to objective response in intrahepatic cholangiocarcinoma.新辅助治疗可使肝内胆管细胞癌产生客观缓解。
HPB (Oxford). 2024 Jul;26(7):938-948. doi: 10.1016/j.hpb.2024.04.003. Epub 2024 Apr 23.
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