Tian Junwei, Zhang Jianzeng, Ding Lu, Qi Xin
Department of Orthopaedic Surgery, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, 130021, Jilin, China.
Department of Joint Surgery and Sports Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, 272029, Shandong, China.
Calcif Tissue Int. 2024 Dec 14;116(1):3. doi: 10.1007/s00223-024-01319-9.
Short and long sleep duration have been linked with adverse health outcomes. However, it is unclear if sleep duration affects the risk of low bone mineral density (BMD) or osteoporosis. We systematically reviewed evidence examining the association between short and long sleep with BMD/osteoporosis. PUBMED, Embase, CENTRAL, Web of Science, and Scopus were examined for studies up to July 15, 2024. We pooled adjusted odds ratio (OR) for the association between sleep and osteoporosis and adjusted linear regression coefficients (β) for BMD. A separate analysis was conducted for males, females, postmenopausal females, and the elderly. 14 studies were included. Three were cohort, while the rest were cross-sectional. The definition of short and long sleep varied among studies. Meta-analysis showed that long (OR 1.19 95% CI 1.05, 1.35 I = 72%) but not short (OR 1.11 95% CI 0.95, 1.29 I = 80%) sleep duration was associated with osteoporosis. Similar results were obtained for females and postmenopausal females. In males, both short and long sleep was associated osteoporosis while no such association was noted in the elderly. Meta-analysis showed that short sleep did not have any significant association with BMD (β - 0.002 95% CI - 0.007, 0.004 I = 0), while long sleep duration was associated with a reduction in BMD (β - 0.017 95% CI - 0.031, - 0.004 I = 0). Separate analyses for males and females revealed non-significant results. Evidence from mostly cross-sectional data suggests that long sleep duration may be a related to BMD and osteoporosis. Short sleep was not found to be related to BMD and osteoporosis, except for males where a significant effect was noted. Given the low-quality evidence, results must be interpreted with caution.
睡眠时间过短和过长都与不良健康后果有关。然而，目前尚不清楚睡眠时间是否会影响低骨矿物质密度（BMD）或骨质疏松症的风险。我们系统地回顾了关于短睡眠和长睡眠与BMD/骨质疏松症之间关联的证据。检索了PUBMED、Embase、CENTRAL、Web of Science和Scopus数据库，查找截至2024年7月15日的相关研究。我们汇总了睡眠与骨质疏松症关联的调整后比值比（OR）以及BMD的调整后线性回归系数（β）。对男性、女性、绝经后女性和老年人进行了单独分析。共纳入14项研究。其中3项为队列研究，其余为横断面研究。不同研究中对短睡眠和长睡眠的定义各不相同。荟萃分析表明，长睡眠时间（OR 1.19，95% CI 1.05，1.35，I = 72%）与骨质疏松症相关，而短睡眠时间（OR 1.11，95% CI 0.95，1.29，I = 80%）与骨质疏松症无关。女性和绝经后女性也得到了类似结果。在男性中，短睡眠和长睡眠均与骨质疏松症相关，而在老年人中未发现此类关联。荟萃分析表明，短睡眠与BMD无显著关联（β -0.002，95% CI -0.007，0.004，I = 0），而长睡眠时间与BMD降低相关（β -0.017，95% CI -0.031，-0.004，I = = 0）。对男性和女性的单独分析结果无统计学意义。大部分横断面数据的证据表明，长睡眠时间可能与BMD和骨质疏松症有关。除了在男性中发现有显著影响外，未发现短睡眠与BMD和骨质疏松症有关。鉴于证据质量较低，对结果的解释必须谨慎。
