一例前列腺特异性抗原（PSA）水平较低的高级别前列腺癌病例。
A case of high-grade prostate cancer with low PSA levels.
作者信息
Bociański Jan, Sklinda Katarzyna, Walecki Jerzy, Rogowski Wojciech, Małek Michał, Kasprowicz Marek, Michałowski Łukasz, Popow Weronika
机构信息
Center of Radiological Diagnostics, The National Medical Institute of the Ministry of Interior and Administration, Wołoska 137, 02-507, Warsaw, Poland.
Clinical Department of Urology and Oncological Urology, The National Medical Institute of the Ministry of Interior and Administration, Wołoska 137, 02-507, Warsaw, Poland.
出版信息
Urol Case Rep. 2025 Aug 16;62:103161. doi: 10.1016/j.eucr.2025.103161. eCollection 2025 Sep.
Prostate-specific antigen (PSA) levels typically correlate with the risk of prostate cancer. However, it is uncommon for an extensive malignant infiltration to occur with persistently low PSA levels. We present a case of a young male with a large tumor originating from the transition zone of the prostate and with low PSA levels This case underscores the biological heterogeneity of prostate cancer and suggests that tumors arising in the transition zone may differ significantly in behavior from those originating in the peripheral zone.
前列腺特异性抗原（PSA）水平通常与前列腺癌风险相关。然而，PSA水平持续较低时发生广泛恶性浸润的情况并不常见。我们报告一例年轻男性病例，其肿瘤较大，起源于前列腺移行带，且PSA水平较低。该病例强调了前列腺癌的生物学异质性，并表明起源于移行带的肿瘤在行为上可能与起源于外周带的肿瘤有显著差异。
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