Armstrong Stephanie A, Boerger Timothy F, Laing Brandon, Tavakoli Samon, Goetschel Kaitlin, Cheok Stephanie, Zwagerman Nathan
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
J Neurol Surg B Skull Base. 2024 Aug 14;86(5):583-590. doi: 10.1055/a-2374-9868. eCollection 2025 Oct.
Olfactory groove meningiomas (OGM) commonly present with olfactory deficits and compression of the frontal lobes. Given the relationship to dietary behaviors, our objective was to evaluate the relationship between OGMs and postoperative weight loss.
Retrospective review of primary resection of meningiomas between 2017 and 2023 at a single institution was conducted. Neurofibromatosis type 2, pregnancy, weight loss medications, or surgeries were excluded. Data collection included preoperative body mass index (preBMI) and postoperative BMI (poBMI) at 3 to 6 and 12 months. Percent BMI change (pcBMI) was calculated by (poBMI - preBMI/preBMI × 100%). IBM SPSS Statistics (Version 27) was used for descriptive statistics and stepwise multiple linear regression.
Ninety-eight patients met inclusion with a mean age of 57.58 years. Three groups were stratified by location: OGM ( = 15), anterior cranial fossa excluding OGM (ACF; = 24), and other (OTH; = 59). Olfactory dysfunction was present in 53.8% of the OGMs. OGM presented with significantly larger lesions (57.25 ± 55.98 mm ) and a higher preBMI (34.58 ± 7.41 kg/m ) than ACF and OTH. A greater pcBMI was seen in OGM at both timepoints (-7.74%, -8.73%). OGM location, tumor volume, and preBMI were found significant on univariate analysis ( < 0.05) and included in multiple linear regression. All regression models were significant ( = 0.001). Location significantly added to the prediction at 3 to 6 and 12 months as well as preBMI at 12 months. In a subanalysis of ACF and OGM, OGM location was significantly associated with negative pcBMI at 3 to 6 and 12 months.
OGMs are associated with higher preoperative weight and greater weight loss postoperatively compared with other locations.
嗅沟脑膜瘤（OGM）通常表现为嗅觉障碍和额叶受压。鉴于其与饮食行为的关系，我们的目的是评估OGM与术后体重减轻之间的关系。
对2017年至2023年在单一机构进行的脑膜瘤初次切除术进行回顾性研究。排除2型神经纤维瘤病、妊娠、减肥药物或手术。数据收集包括术前体重指数（preBMI）以及术后3至6个月和12个月时的BMI（poBMI）。BMI变化百分比（pcBMI）通过（poBMI - preBMI/preBMI×100%）计算。使用IBM SPSS Statistics（版本27）进行描述性统计和逐步多元线性回归分析。
98例患者符合纳入标准，平均年龄为57.58岁。根据位置分为三组：OGM组（n = 15）、不包括OGM的前颅窝组（ACF；n = 24）和其他组（OTH；n = 59）。53.8%的OGM存在嗅觉功能障碍。与ACF组和OTH组相比，OGM组的病变明显更大（57.25±55.98mm），术前BMI更高（34.58±7.41kg/m²）。在两个时间点，OGM组的pcBMI变化更大（-7.74%，-8.73%）。单因素分析发现OGM位置、肿瘤体积和术前BMI具有统计学意义（P < 0.05），并纳入多元线性回归分析。所有回归模型均具有统计学意义（P = 0.001）。位置因素在术后3至6个月和12个月以及术后12个月的术前BMI预测中显著增加。在ACF组和OGM组的亚分析中，OGM位置在术后3至6个月和12个月与负向pcBMI显著相关。
与其他部位相比，OGM与更高的术前体重和更大的术后体重减轻相关。
