Ursea N, Cristian R, Manciulea M
Med Interne. 1985 Oct-Dec;23(4):249-52.
The value of C3, of the cleavage C3 components and of the B factor were determined in 25 normal controls and in 22 patients with chronic renal failure (CRF), iteratively dialyzed. Low values of C3 and progressive hypomorphism of the cleavage components of C3 were observed in the patients at the three moments of determination. The activity of the B factor was also found significantly decreased in the patients. Our results indicated an activation of the complement alternative pathway in the dialyzed patients but the activation through the classic pathway, could not be excluded either. It is concluded that this activation might be due to the initial disease which generated CRF but also to some factors transported by hemodialysis.
在25名正常对照者和22名反复透析的慢性肾衰竭（CRF）患者中测定了C3、C3裂解成分及B因子的值。在测定的三个时间点，观察到患者的C3值较低且C3裂解成分呈进行性亚态。还发现患者的B因子活性显著降低。我们的结果表明，透析患者的补体替代途径被激活，但经典途径的激活也不能排除。结论是，这种激活可能是由于导致CRF的初始疾病，也可能是由于血液透析所传递的某些因素。
