Jin-Feng Fu, Ping-Ping Wang, Xiong Fu, Chin-Ping Tan, Chun Chen, Yun-Ping Peng
SCUT-Zhuhai Institute of Modern Industrial Innovation, School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
J Food Sci. 2025 Jun;90(6):e70267. doi: 10.1111/1750-3841.70267.
Obesity is a major public health concern that increases the risk of diseases associated with metabolic disorders. Polyphenols, an important plant-derived phytonutrient, are widely present in diets. The dietary polyphenols have great potential to be used in reducing obesity and obesity-related diseases. Purposely, this review aims to summarize the current research on the relationship between dietary polyphenols and obesity. We elucidated the pathophysiology and current treatment strategies for obesity, as well as outlined the dietary sources of polyphenols and their metabolism in humans. Particularly, the potential antiobesity properties of dietary polyphenols in experimental animals and clinical tests are highlighted. We further provide insights into the mechanisms underlying the beneficial effects of dietary polyphenols on obesity. Upcoming investigations need to focus on the effects of food processing and human metabolic activity on polyphenols to improve the biological functions of polyphenols in foods and their precise delivery and bioavailability in the body. Conclusively, our work discussed the hotpots of polyphenols bioavailability, exploitation, and beneficial effects on obesity, which provides valuable information for polyphenols in antiobesity.
肥胖是一个主要的公共卫生问题，它会增加与代谢紊乱相关疾病的风险。多酚是一种重要的植物源植物营养素，广泛存在于饮食中。膳食多酚在减轻肥胖及肥胖相关疾病方面具有巨大的应用潜力。本文旨在总结目前关于膳食多酚与肥胖之间关系的研究。我们阐述了肥胖的病理生理学和当前的治疗策略，概述了多酚的膳食来源及其在人体内的代谢。特别强调了膳食多酚在实验动物和临床试验中的潜在抗肥胖特性。我们进一步深入探讨了膳食多酚对肥胖有益作用的潜在机制。未来的研究需要关注食品加工和人体代谢活动对多酚的影响，以提高多酚在食品中的生物学功能及其在体内的精准递送和生物利用度。总之，我们的工作讨论了多酚生物利用度、开发利用及其对肥胖有益作用的热点问题，为多酚在抗肥胖方面提供了有价值的信息。
