• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1,3-茚二酮类化合物含有全饱和螺环戊烷的DABCO催化高非对映选择性合成，涉及2-(2'-氧代烷基)-1,3-茚二酮和硝基苯乙烯。

DABCO-catalysed highly diastereoselective synthesis of 1,3-indandione containing fully saturated spirocyclopentanes involving 2-(2'-ketoalkyl)-1,3-indandiones and nitrostyrenes.

作者信息

Mishra Gitanjali, Bobonga Missa Saril, Islam Khadimul, Chakraborty Arundhuti, Thirupathi Barla

机构信息

Department of Chemical Sciences, Indian Institute of Science Education & Research Berhampur, Transit Campus Govt. ITI Building, NH 59, Engineering School Road, Ganjam District Berhampur 760010 Odisha India

出版信息

RSC Adv. 2025 Aug 28;15(37):30768-30780. doi: 10.1039/d5ra04224k. eCollection 2025 Aug 22.

DOI:10.1039/d5ra04224k
PMID:40895748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12395038/
Abstract

Highly functionalized 1,3-indandione containing spirocyclopentanes has been synthesized by reacting nitrostyrenes with 2-(2'-ketoalkyl)-1,3-indandiones using a catalytic amount of DABCO. The resultant products possess three consecutive chiral centres in addition to a spirocyclic centre and are obtained in a highly diastereoselective manner using a catalytic amount of the organic base, DABCO.

摘要

通过使用催化量的1,4 - 二氮杂双环[2.2.2]辛烷（DABCO）使硝基苯乙烯与2-(2'-酮烷基)-1,3 - 茚二酮反应，合成了含有螺环戊烷的高度官能化的1,3 - 茚二酮。所得产物除了一个螺环中心外还具有三个连续的手性中心，并且使用催化量的有机碱DABCO以高度非对映选择性的方式获得。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/1ba24f1f51a1/d5ra04224k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/667f45e1f410/d5ra04224k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/d92143bbf2d0/d5ra04224k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/353310d2e0d5/d5ra04224k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/1ba24f1f51a1/d5ra04224k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/667f45e1f410/d5ra04224k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/d92143bbf2d0/d5ra04224k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/353310d2e0d5/d5ra04224k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7862/12395038/1ba24f1f51a1/d5ra04224k-s4.jpg

相似文献

1
DABCO-catalysed highly diastereoselective synthesis of 1,3-indandione containing fully saturated spirocyclopentanes involving 2-(2'-ketoalkyl)-1,3-indandiones and nitrostyrenes.1,3-茚二酮类化合物含有全饱和螺环戊烷的DABCO催化高非对映选择性合成，涉及2-(2'-氧代烷基)-1,3-茚二酮和硝基苯乙烯。
RSC Adv. 2025 Aug 28;15(37):30768-30780. doi: 10.1039/d5ra04224k. eCollection 2025 Aug 22.
2
Synthesis of Highly Functionalized Spirocycles and Pentafulvene-Containing Dyes Involving 2-(2'-ketoalkyl)-1,3-indandiones.涉及2-(2'-氧代烷基)-1,3-茚二酮的高官能化螺环和含戊搭烯染料的合成。
Chemistry. 2023 Dec 19;29(71):e202301976. doi: 10.1002/chem.202301976. Epub 2023 Nov 13.
3
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
4
Organic Synthesis Away from Equilibrium: Contrathermodynamic Transformations Enabled by Excited-State Electron Transfer.远离平衡态的有机合成：由激发态电子转移实现的反热力学转变
Acc Chem Res. 2024 Jul 2;57(13):1827-1838. doi: 10.1021/acs.accounts.4c00227. Epub 2024 Jun 21.
5
Regioselective and Chemodivergent Synthesis of 1,3-Indandione-Fused Spirocyclopentenes and Spiropyrrolidines.1,3-茚二酮稠合螺环戊烯和螺吡咯烷的区域选择性和化学发散性合成
J Org Chem. 2025 Jul 4;90(26):8886-8902. doi: 10.1021/acs.joc.5c00490. Epub 2025 Jun 17.
6
Cost-effectiveness of using prognostic information to select women with breast cancer for adjuvant systemic therapy.利用预后信息为乳腺癌患者选择辅助性全身治疗的成本效益
Health Technol Assess. 2006 Sep;10(34):iii-iv, ix-xi, 1-204. doi: 10.3310/hta10340.
7
Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.后部皮质萎缩的人口统计学、临床、生物标志物和神经病理学相关性：一项国际队列研究和个体参与者数据荟萃分析。
Lancet Neurol. 2024 Feb;23(2):168-177. doi: 10.1016/S1474-4422(23)00414-3.
8
Health professionals' experience of teamwork education in acute hospital settings: a systematic review of qualitative literature.医疗专业人员在急症医院环境中团队合作教育的经验：对定性文献的系统综述
JBI Database System Rev Implement Rep. 2016 Apr;14(4):96-137. doi: 10.11124/JBISRIR-2016-1843.
9
Genetic determinants of testicular sperm extraction outcomes: insights from a large multicentre study of men with non-obstructive azoospermia.睾丸精子提取结果的遗传决定因素：来自一项针对非梗阻性无精子症男性的大型多中心研究的见解
Hum Reprod Open. 2025 Aug 29;2025(3):hoaf049. doi: 10.1093/hropen/hoaf049. eCollection 2025.
10
[Research progress of peptide recognition-guided strategies for exosome isolation and enrichment].[基于肽识别的外泌体分离与富集策略的研究进展]
Se Pu. 2025 May;43(5):446-454. doi: 10.3724/SP.J.1123.2024.10015.

本文引用的文献

1
Rapid Assembly of 1,3-Dicarbonyl Fused 5-phenyl-1-Azabicyclo[3.1.0]hexanes and Their Cytotoxic Activities.1,3-二羰基稠合的5-苯基-1-氮杂双环[3.1.0]己烷的快速组装及其细胞毒性活性
Org Lett. 2025 Jan 24;27(3):761-766. doi: 10.1021/acs.orglett.4c04394. Epub 2025 Jan 13.
2
Synthesis of Highly Functionalized Spirocycles and Pentafulvene-Containing Dyes Involving 2-(2'-ketoalkyl)-1,3-indandiones.涉及2-(2'-氧代烷基)-1,3-茚二酮的高官能化螺环和含戊搭烯染料的合成。
Chemistry. 2023 Dec 19;29(71):e202301976. doi: 10.1002/chem.202301976. Epub 2023 Nov 13.
3
A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A.
一种获得高官能化二苯并[3.2.1]辛二烯酮的方法：在构建 Rubialatin A 的 6/6/5/6/6 碳骨架中的应用。
J Org Chem. 2022 Sep 16;87(18):11925-11938. doi: 10.1021/acs.joc.2c00340. Epub 2022 Apr 27.
4
Meroindenon and Merochlorins E and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus .海洋来源的 属细菌代谢产物中的倍半萜类抗生素米罗地诺和米罗氯林 E、F
Org Lett. 2019 Aug 2;21(15):5779-5783. doi: 10.1021/acs.orglett.9b01440. Epub 2019 Jul 12.
5
Highly enantioselective [3+2] cycloaddition of vinylcyclopropane with nitroalkenes catalyzed by palladium(0) with a chiral bis(tert-amine) ligand.钯(0)与手性双(叔胺)配体催化乙烯基环丙烷与硝基烯烃的高度对映选择性[3+2]环加成反应。
Chemistry. 2015 Feb 2;21(6):2335-8. doi: 10.1002/chem.201405407. Epub 2014 Dec 11.
6
Indanostatin, a new neuroprotective compound from Streptomyces sp.茚达他汀，一种来自链霉菌属的新型神经保护化合物。
J Antibiot (Tokyo). 2013 Dec;66(12):731-3. doi: 10.1038/ja.2013.80. Epub 2013 Aug 28.
7
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives.嘧啶衍生物的合成、药理学评价及对接研究。
Eur J Med Chem. 2012 Dec;58:478-84. doi: 10.1016/j.ejmech.2012.09.050. Epub 2012 Oct 16.
8
Efficient solution-processed bulk heterojunction solar cells by antiparallel supramolecular arrangement of dipolar donor-acceptor dyes.通过偶极给体-受体染料的反平行超分子排列实现高效溶液处理体异质结太阳能电池。
Angew Chem Int Ed Engl. 2011 Dec 2;50(49):11628-32. doi: 10.1002/anie.201105133. Epub 2011 Oct 18.
9
Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors.设计、合成及生物评价吲唑-2-芳腙亚甲基-1,3-二酮和吲哚-2-芳基亚氨基亚甲基-3-酮类化合物作为β-淀粉样蛋白聚集抑制剂。
Eur J Med Chem. 2010 Apr;45(4):1359-66. doi: 10.1016/j.ejmech.2009.12.029. Epub 2009 Dec 23.
10
Fredericamycin A, a new antitumor antibiotic. II. Biological properties.弗雷德霉素A，一种新型抗肿瘤抗生素。II. 生物学特性。
J Antibiot (Tokyo). 1981 Nov;34(11):1402-7. doi: 10.7164/antibiotics.34.1402.