Department of Chemistry and Nanoscience , Ewha Womans University , Seoul 03760 , Republic of Korea.
Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
Org Lett. 2019 Aug 2;21(15):5779-5783. doi: 10.1021/acs.orglett.9b01440. Epub 2019 Jul 12.
Meroterpenoids, meroindenon () and merochlorins E () and F (), were isolated from a marine-derived bacterium belonging to the genus . Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds - possess a tetrahydroxynaphthalene core and a C-isoprene unit. Compounds and exhibited strong antibacterial activities against , , and , with a range of MIC values from 1 to 2 μg/mL.
海洋来源细菌 属中分离得到的倍半萜类化合物 meroindenon () 和 merochlorins E () 和 F ()。采用 MS、UV、ECD 和 NMR 光谱数据分析等方法确定了它们的化学结构。化合物 - 具有四羟基萘核和 C-异戊二烯单元。化合物 和 对 、 、 和 表现出较强的抗菌活性，MIC 值范围为 1-2μg/mL。
