Chavan Nagesh Dhanaji, Sarveswari S, Vijayakumar V
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology Vellore 632016 India
RSC Adv. 2025 Aug 27;15(37):30576-30604. doi: 10.1039/d5ra00534e. eCollection 2025 Aug 22.
Quinoline is a heterocyclic compound that plays a fundamental role in the study of chemical compounds, highlighting its importance in drug development. Its basic framework is crucial for synthesizing new pharmaceutical substances and facilitating the development of innovative drugs with significant therapeutic potential. A thorough examination of quinoline and its various derivatives, which exhibit a wide range of biological activities, greatly contributes to groundbreaking drug discoveries that can transform the medical industry. This review presents a carefully curated collection of references related to quinoline, covering a unique range of quinoline-based medications currently available on the market, including antimalarial and anticancer drugs. It provides a comprehensive overview of the therapeutic potential of these compounds. Furthermore, the review aims to clarify and explain the complex biological properties of quinoline derivatives, particularly their antimalarial and anticancer activities. This insight will enhance our understanding of the therapeutic potential and efficacy of these compounds in combating malaria and cancer, diseases that affect millions of people worldwide.
喹啉是一种杂环化合物，在化合物研究中发挥着重要作用，凸显了其在药物开发中的重要性。其基本框架对于合成新的药物物质以及促进具有重大治疗潜力的创新药物的开发至关重要。对喹啉及其各种衍生物进行全面研究，这些衍生物具有广泛的生物活性，极大地推动了能够变革医疗行业的突破性药物发现。本综述精心收集了与喹啉相关的参考文献，涵盖了目前市场上一系列独特的基于喹啉的药物，包括抗疟药和抗癌药。它全面概述了这些化合物的治疗潜力。此外，该综述旨在阐明和解释喹啉衍生物复杂的生物学特性，特别是它们的抗疟和抗癌活性。这一见解将增进我们对这些化合物在对抗疟疾和癌症（这两种影响全球数百万人的疾病）方面的治疗潜力和疗效的理解。
