Latterman Connor, Imahiyerobo Joyce I
Dermatology, Vibrant Dermatology, Dedham, USA.
Cureus. 2025 Jul 31;17(7):e89116. doi: 10.7759/cureus.89116. eCollection 2025 Jul.
Hypopigmented scars present a cosmetic and psychological burden, especially in patients of darker skin types. Novel strategies to restore pigment are limited and often ineffective. A 48-year-old woman presented with a complaint of hypopigmented burn scars on both arms. Two months prior, the patient received an intense pulsed light (IPL) treatment at a medical spa. At her initial consultation, she was prescribed Ruxolitinib (a Janus Kinase (JAK) inhibitor) 1.5% (Opzelura) cream to use each morning and tacrolimus 0.1% ointment (a calcineurin inhibitor) to use every night. After six weeks of applying topicals, she then received two non-ablative 1927 nm fractional thulium laser treatments with bimatoprost 0.03% ophthalmic solution (Latisse) six weeks apart while continuing her topical routine at home. After 18 weeks of treatment, most of the patient's pigment had returned. The laser created micro-channels for enhanced topical absorption, while the topical agents reduced inflammation and promoted melanogenesis. This combination offers a promising, non-invasive treatment for hypopigmented burn scars.
色素减退性瘢痕会带来美容和心理负担，尤其是对于肤色较深的患者。恢复色素的新策略有限且往往效果不佳。一名48岁女性因双臂色素减退性烧伤瘢痕前来就诊。两个月前，该患者在一家医疗美容中心接受了强脉冲光（IPL）治疗。在初次咨询时，她被开了1.5%的鲁索替尼（一种 Janus 激酶（JAK）抑制剂）乳膏（Opzelura），每天早上使用，以及0.1%的他克莫司软膏（一种钙调神经磷酸酶抑制剂），每晚使用。在局部用药六周后，她接着接受了两次非剥脱性1927纳米铥激光治疗，间隔六周，并在每次治疗时外用0.03%比马前列素滴眼液（Latisse），同时在家继续进行局部用药常规治疗。经过18周的治疗，患者大部分色素已恢复。激光产生微通道以增强局部吸收，而局部用药可减轻炎症并促进黑素生成。这种联合治疗为色素减退性烧伤瘢痕提供了一种有前景的非侵入性治疗方法。
