Carney Bonnie C, McKesey Jacqueline P, Rosenthal Dean S, Shupp Jeffrey W
Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D.C.; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, D.C.; and The Burn Center, MedStar Washington Hospital Center, Washington, D.C.
Plast Reconstr Surg Glob Open. 2018 Jan 18;6(1):e1642. doi: 10.1097/GOX.0000000000001642. eCollection 2018 Jan.
Dyspigmentation in burn scars can contribute to the development of psychosocial complications after injury and can be detrimental to social reintegration and quality of life for burn survivors. Although treatments for skin lightening to treat hyperpigmentation have been well reviewed in the literature, skin-darkening strategies to treat hypopigmentation have not. The following potential treatment options in the context of burn hypertrophic scar will be discussed: use of the melanocyte-keratinocyte transplantation procedure, use of ectopic synthetic analogues of alpha-melanocyte stimulating hormone to initiate melanogenesis, and use of FK506 to induce melanogenesis. A proposed future direction of research in laser-assisted drug delivery of inducers of local melanin production, with the hope of developing a targeted, effective approach to dyspigmentation in hypertrophic scar is also discussed.
烧伤瘢痕色素沉着可导致受伤后心理社会并发症的发生，且不利于烧伤幸存者重新融入社会和生活质量。尽管文献中已对治疗色素沉着的皮肤美白疗法进行了充分综述，但治疗色素减退的皮肤变黑策略却未被提及。本文将讨论在烧伤增生性瘢痕背景下的以下潜在治疗选择：黑素细胞 - 角质形成细胞移植术的应用、使用α - 黑素细胞刺激激素的异位合成类似物启动黑素生成，以及使用FK506诱导黑素生成。本文还讨论了激光辅助药物递送局部黑素生成诱导剂的未来研究方向，希望能开发出一种针对增生性瘢痕色素沉着的靶向、有效方法。
