Chun Soo Il
Chun Aesthetic and Laser Clinic, Seoul, South Korea.
Clin Cosmet Investig Dermatol. 2024 Aug 27;17:1931-1942. doi: 10.2147/CCID.S468326. eCollection 2024.
Acne vulgaris remains one of the most common and problematic dermatological conditions. Recently, a fractional 1927 nm thulium laser has been developed with specific water absorption characteristics which may be of interest in the treatment of acne.
Nine consecutive Korean subjects, 6 females and 3 males, ages ranging from 13 to 33 yr, presented with a mixture of inflammatory and noninflammatory acne. Baseline clinical photography, image analysis and lesion counts were performed. A fractional 1927 nm thulium laser (FTL) delivered 6 treatment sessions in 5 subjects and 5 sessions in 4 subjects, 4 weeks between sessions. Pain during treatment was assessed. At 32 weeks after the last treatment session, an independent Investigator Global Assessment (IGA) performed lesion counts and graded the severity of the acne at baseline and the final assessment on a quintile scale. Data were analyzed statistically.
All 9 subjects completed the study with significant reductions in the inflammatory and noninflammatory lesions (P values 0.0012 and 0.0081, respectively) with overall lesion counts at the final assessment ranging from 60% to 97.1%, and acne grades in the IGA dropping by an average of 1.67 (range 1 to 3 grades). There was no significant difference in lesion counts or acne grades between the subjects who had 6 treatments and those who had 5 (P = 0.7695). Mild pain was reported during treatment, and no adverse events were reported by either the subjects or investigator.
The FTL at the parameters used in the present study caused disruption to the upper portion of the affected follicles and sebaceous glands under an intact stratum corneum, thereby destroying or damaging the causative . The superficial controlled coagulation additionally induced follicular remodeling and tissue regeneration, potentially contributing to the noticeable results in inflammatory and noninflammatory acne lesions.
寻常痤疮仍然是最常见且棘手的皮肤病之一。最近，一种具有特定水吸收特性的1927纳米掺铥分数激光已被研发出来，这可能对痤疮治疗具有重要意义。
连续纳入9名韩国受试者，其中6名女性，3名男性，年龄在13至33岁之间，均患有炎性和非炎性痤疮混合症状。进行了基线临床摄影、图像分析及皮损计数。1927纳米掺铥分数激光（FTL）对5名受试者进行了6次治疗，对4名受试者进行了5次治疗，每次治疗间隔4周。评估了治疗过程中的疼痛情况。在最后一次治疗后32周，由独立研究者进行整体评估（IGA），计数皮损数量，并按照五分制对基线和最终评估时的痤疮严重程度进行分级。对数据进行统计学分析。
所有9名受试者均完成了研究，炎性和非炎性皮损均显著减少（P值分别为0.0012和0.0081），最终评估时整体皮损计数减少了60%至97.1%，IGA中的痤疮分级平均下降了1.67（范围为1至3级）。接受6次治疗的受试者与接受5次治疗的受试者在皮损计数或痤疮分级上无显著差异（P = 0.7695）。治疗过程中报告有轻度疼痛，受试者和研究者均未报告不良事件。
本研究中使用的参数下的FTL在完整角质层下对受影响的毛囊和皮脂腺上部造成破坏，从而破坏或损伤病因。表面可控性凝固还额外诱导了毛囊重塑和组织再生，可能是炎性和非炎性痤疮皮损取得显著效果的原因。
