T Sandhiya, Adalarasan Sahasyaa, U Samyuktha, Md Suganeshwari, R Ramya
Medicine School, Madras Medical College, Chennai, IND.
Institute of Pharmacology, Madras Medical College, Chennai, IND.
Cureus. 2025 Jul 29;17(7):e88956. doi: 10.7759/cureus.88956. eCollection 2025 Jul.
Introduction Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Among its complications, diabetic foot ulcers (DFUs) pose a significant healthcare challenge which result from impaired healing and infection risks, demanding better therapies. The aloe vera extract promotes wound healing by enhancing tissue regeneration and offering antimicrobial effects. This study evaluates its therapeutic effect on DFUs through a randomized controlled trial. Methods The study involved 60 patients sampled and followed up between May 1, 2025, and June 15, 2025. It compared wound healing outcomes between two groups selected by the lottery method. A control group (30 patients) receiving standard care and a blinded study group (30 patients) treated with aloe vera extract were assessed using the Bates-Jensen Wound Assessment Tool (BWAT). Wound healing was monitored on days 0, 14, and 28, and data were analyzed for significant differences. Results The study's demographic data showed comparable baseline characteristics between groups, with no adverse effects from aloe vera use. BWAT scores were recorded on days 0, 14, and 28, and the average scores for the case group and the control group, respectively, were 42±3.11 and 43±3.58 on day 0, 31±2.16 and 35±2.61 on day 14, 19±2.17 and 25±2.17 on day 28. Average scores decreased more rapidly in the case group than in the control group. A chi-square test confirmed a significant association between aloe vera treatment and enhanced wound healing (p = 0.0029). Conclusion This single-blinded randomized controlled trial shows that topical aloe vera significantly improves DFU healing compared to standard care. Its effects are likely due to the promotion of angiogenesis, reduction in inflammation, and antimicrobial action. Aloe vera is a safe, affordable option, especially for low-resource settings. Larger studies with longer follow-up are needed to confirm and expand its clinical use.
引言 糖尿病是一种慢性代谢紊乱疾病，其特征为胰岛素分泌缺陷、胰岛素作用缺陷或两者兼而有之导致的高血糖。在其并发症中，糖尿病足溃疡（DFUs）带来了重大的医疗挑战，这是由于愈合受损和感染风险所致，需要更好的治疗方法。芦荟提取物通过促进组织再生和提供抗菌作用来促进伤口愈合。本研究通过随机对照试验评估其对糖尿病足溃疡的治疗效果。方法 该研究纳入了60例患者，于2025年5月1日至2025年6月15日进行采样和随访。通过抽签法将患者分为两组，并比较两组的伤口愈合结果。使用贝茨 - 詹森伤口评估工具（BWAT）对接受标准护理的对照组（30例患者）和接受芦荟提取物治疗的盲法研究组（30例患者）进行评估。在第0、14和28天监测伤口愈合情况，并分析数据以找出显著差异。结果 该研究的人口统计学数据显示两组之间基线特征具有可比性，使用芦荟没有不良反应。在第0、14和28天记录BWAT评分，病例组和对照组在第0天的平均评分分别为42±3.11和43±3.58，第14天分别为31±2.16和35±2.61，第28天分别为19±2.17和25±2.17。病例组的平均评分下降速度比对照组更快。卡方检验证实芦荟治疗与伤口愈合增强之间存在显著关联（p = 0.0029）。结论 这项单盲随机对照试验表明，与标准护理相比，局部应用芦荟能显著改善糖尿病足溃疡的愈合。其效果可能归因于促进血管生成、减轻炎症和抗菌作用。芦荟是一种安全、经济实惠的选择，尤其适用于资源匮乏地区。需要进行更大规模、更长随访期的研究来确认并扩大其临床应用。
