Batten Seth R, Bang Dan, Kopell Brian H, Davis Arianna N, Heflin Matthew, Fu Qixiu, Perl Ofer, Ziafat Kimia, Hashemi Alice, Saez Ignacio, Barbosa Leonardo S, Twomey Thomas, Lohrenz Terry, White Jason P, Dayan Peter, Charney Alexander W, Figee Martijn, Mayberg Helen S, Kishida Kenneth T, Gu Xiaosi, Montague P Read
Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Nat Hum Behav. 2024 Apr;8(4):718-728. doi: 10.1038/s41562-024-01831-w. Epub 2024 Feb 26.
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players. They rejected more offers in the human than the computer condition, an effect of social context associated with higher overall levels of dopamine but not serotonin. Regardless of the social context, relative changes in dopamine tracked trial-by-trial changes in offer value-akin to reward prediction errors-whereas serotonin tracked the current offer value. These results show that dopamine and serotonin fluctuations in one of the basal ganglia's main output structures reflect distinct social context and value signals.
多巴胺和血清素被认为可引导社会行为。然而，在人类中，我们尚未能够在社交互动展开时研究神经调质的动态变化。在此，我们在最后通牒博弈期间从人类黑质网状部获得了多巴胺和血清素的亚秒级估计值。参与者为正在接受清醒脑部手术的帕金森病患者，他们必须接受或拒绝来自人类和计算机玩家的不同公平程度的金钱提议。与计算机条件相比，他们拒绝人类提议的次数更多，这种社会背景效应与多巴胺的总体水平较高有关，而与血清素无关。无论社会背景如何，多巴胺的相对变化跟踪了提议价值的逐次试验变化——类似于奖励预测误差——而血清素则跟踪了当前提议价值。这些结果表明，基底神经节主要输出结构之一中的多巴胺和血清素波动反映了不同的社会背景和价值信号。
