Reyers I, Hennissen A, Donati M B, Hornstra G, de Gaetano G
Thromb Haemost. 1985 Oct 30;54(3):619-21.
A trial of the efficacy of aspirin in the prevention of thrombotic occlusion of an "aortic loop" in rats was made simultaneously by two experimental surgeons. A relatively large dose of aspirin (80-100 mg/kg/day) was used, starting two days before operation. It appeared that aspirin was of limited benefit, reducing thrombotic occlusions by about 17% seven days after the insertion of the loop into the abdominal aorta. Although the average occlusion time was prolonged by about 17% in aspirin-treated animals, the separate trials gave no conclusive result. When the data from both operators were pooled, a statistically significant protection by aspirin was apparent (p = 0.02), by a two-tailed Student's t test. However, on using the powerful non-parametric randomization test, the occlusion times in control and aspirin-treated groups appeared not statistically different (p = 0.07). No significant difference was also found between control and treated groups when data were analyzed by X2 test. Independently of the statistical analysis, these data are quite similar to those obtained from aspirin trials in men surviving myocardial infarction. This finding points to the usefulness of the aorta loop as an animal model for arterial thrombosis.
两位实验外科医生同时对阿司匹林预防大鼠“主动脉袢”血栓形成闭塞的疗效进行了试验。使用了相对大剂量的阿司匹林（80 - 100毫克/千克/天），从手术前两日开始给药。结果显示阿司匹林的益处有限，在将袢植入腹主动脉七天后，血栓形成闭塞减少了约17%。虽然在接受阿司匹林治疗的动物中平均闭塞时间延长了约17%，但单独的试验没有得出确凿的结果。当将两位操作者的数据汇总时，通过双尾学生t检验，阿司匹林具有统计学上显著的保护作用（p = 0.02）。然而，使用强大的非参数随机化检验时，对照组和阿司匹林治疗组的闭塞时间在统计学上没有差异（p = 0.07）。当用X²检验分析数据时，对照组和治疗组之间也未发现显著差异。与统计分析无关，这些数据与在心肌梗死存活男性中进行的阿司匹林试验所获得的数据非常相似。这一发现表明主动脉袢作为动脉血栓形成动物模型的有用性。
