Ghabaee Mojdeh, Eskandarieh Sharareh, Izadi Neda, Hosseini Siavash, Kiani Iman, Jameie Melika, Azizan Zahra, Mojahed Nahid
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC Neurol. 2025 Sep 2;25(1):374. doi: 10.1186/s12883-025-04406-y.
Stroke remains a major cause of disability and mortality worldwide, requiring comprehensive data collection for better management strategies. The Endovascular Thrombolysis Registry in Acute Ischemic Stroke of Iran (ETRAISI) was established March 21, 2023, to systematically document stroke epidemiology, treatment approaches, and outcomes in Iran. This study presents an analysis of registry data, focusing on patient characteristics, treatment time scales, and functional outcomes.
A total of 115 patients diagnosed with acute stroke were enrolled at ETRAISI between March 21, 2023, and March 19, 2024. Clinical and demographic data, including stroke subtype, risk factors, treatment modalities, and outcome measures, were collected. Treatment time scales, such as door-to-needle time (DTN) for thrombolysis and door-to-groin puncture time (DTP) for thrombectomy, were analyzed. Factors associated with National Institutes of Health Stroke Scale (NIHSS) at discharge were assessed using multiple linear regression.
Among 313 patients admitted at hospital as possible acute ischemic stroke (AIS), a total of 158 patients' candidate for intra-venous thrombolysis (IVT) or mechanical thrombectomy (MT) within 6-hours of onset, 115 enrolled, 81 patients (70.4%) underwent IVT, 8 (7.0%) patients received MT, and 26 patients (22.6%) underwent bridging therapy. The most common stroke risk factors were hypertension in 77 patients (67.0%), followed by diabetes in 39 (33.9%), and ischemic heart disease in 33 patients (28.7%). The median (IQR) of DTN was 65 (48-84.5) minutes, while the median (IQR) of DTP was 109 (75-158) minutes. The most frequent stroke etiology was undetermined observed in 33% patients. Multiple linear regression identified National Institutes of Health Stroke Scale (NIHSS) at admission, age, diastolic blood pressure, and treatment related complication were significantly associated with functional outcomes (p < 0.05).
This study reported stroke management and outcomes in Iran. Identifying treatment time tracker and outcome related factors may inform policy changes and improve acute stroke care in Iran and Other developing countries. Benchmarking these findings against international registries can guide targeted interventions for optimizing stroke treatment.
中风仍然是全球残疾和死亡的主要原因，需要收集全面的数据以制定更好的管理策略。伊朗急性缺血性中风血管内溶栓登记处（ETRAISI）于2023年3月21日成立，旨在系统记录伊朗的中风流行病学、治疗方法和治疗结果。本研究对登记数据进行了分析，重点关注患者特征、治疗时间范围和功能结局。
2023年3月21日至2024年3月19日期间，共有115例被诊断为急性中风的患者在ETRAISI登记入组。收集了临床和人口统计学数据，包括中风亚型、危险因素、治疗方式和结局指标。分析了治疗时间范围，如溶栓的门到针时间（DTN）和取栓的门到股动脉穿刺时间（DTP）。使用多元线性回归评估与出院时美国国立卫生研究院卒中量表（NIHSS）相关的因素。
在313例因可能的急性缺血性中风（AIS）入院的患者中，共有158例患者在发病6小时内符合静脉溶栓（IVT）或机械取栓（MT）条件，115例登记入组，81例患者（70.4%）接受了IVT，8例（7.0%）患者接受了MT，26例患者（22.6%）接受了桥接治疗。最常见的中风危险因素是77例患者（67.0%）患有高血压，其次是39例（33.9%）患有糖尿病，33例患者（28.7%）患有缺血性心脏病。DTN的中位数（IQR）为65（48 - 84.5）分钟，而DTP的中位数（IQR）为109（75 - 158）分钟。最常见的中风病因在33%的患者中未确定。多元线性回归确定入院时的美国国立卫生研究院卒中量表（NIHSS）、年龄、舒张压和治疗相关并发症与功能结局显著相关（p < 0.05）。
本研究报告了伊朗的中风管理和治疗结果。确定治疗时间追踪指标和与结局相关的因素可能为政策改变提供依据，并改善伊朗和其他发展中国家的急性中风护理。将这些结果与国际登记处进行对比可以指导有针对性的干预措施，以优化中风治疗。
