Wu Xiaosheng, Zhan Xueqin, Ouyang Chao
Department of Respiratory and Critical Care Medicine, Nanchang People's Hospital, Nanchang, Jiangxi Province, PR China.
Nursing Department, Nanchang People's Hospital, Nanchang, Jiangxi Province, PR China.
Medicine (Baltimore). 2025 Aug 29;104(35):e44249. doi: 10.1097/MD.0000000000044249.
The role of 25-hydroxyvitamin D (25(OH)D) in disease has attracted much attention. However current research findings on the relationship between 25(OH)D and asthma are not completely consistent. This study aims to explore the potential causal relationship between 25(OH)D levels and asthma using a bidirectional Mendelian randomization (MR) approach. Data from large genome-wide association studies related to the study phenotypes were utilized. Genetic correlation data for 25(OH)D were obtained from the European Bioinformatics Institute database, and genetic correlation data for asthma risk were sourced from the FinnGen biobank. A 2-sample MR analysis was conducted, primarily using the inverse-variance weighted method to assess the impact of 25(OH)D levels on asthma. Sensitivity analyses and horizontal pleiotropy tests were performed to ensure the reliability of the results. Additionally, a reverse MR analysis was conducted to explore potential reverse causal relationships. The MR analysis indicated no significant causal relationship between 25(OH)D levels and allergic asthma (odds ratio [OR] = 1.13, 95% CI: 0.91-1.40, P = .259) or nonallergic asthma (OR = 1.06, 95% CI: 0.89-1.28, P = .501). Furthermore, the reverse MR analysis did not reveal a significant impact of asthma on 25(OH)D levels (allergic asthma: OR = 1.01, 95% CI: 0.99-1.02, P = .363; nonallergic asthma: OR = 1.03, 95% CI: 0.98-1.07, P = .235). The consistency of results across sensitivity analyses and various statistical methods supports this conclusion. Evidence from bidirectional MR suggests no causal relationship between 25(OH)D levels and either allergic or nonallergic asthma.
25-羟基维生素D（25(OH)D）在疾病中的作用已引起广泛关注。然而，目前关于25(OH)D与哮喘之间关系的研究结果并不完全一致。本研究旨在采用双向孟德尔随机化（MR）方法探讨25(OH)D水平与哮喘之间的潜在因果关系。利用了与研究表型相关的大型全基因组关联研究的数据。25(OH)D的遗传相关数据来自欧洲生物信息学研究所数据库，哮喘风险的遗传相关数据来自芬兰基因库生物样本库。进行了两样本MR分析，主要使用逆方差加权法评估25(OH)D水平对哮喘的影响。进行了敏感性分析和水平多效性检验以确保结果的可靠性。此外，还进行了反向MR分析以探索潜在的反向因果关系。MR分析表明，25(OH)D水平与过敏性哮喘（优势比[OR]=1.13，95%置信区间：0.91-1.40，P=0.259）或非过敏性哮喘（OR=1.06，95%置信区间：0.89-1.28，P=0.501）之间无显著因果关系。此外，反向MR分析未发现哮喘对25(OH)D水平有显著影响（过敏性哮喘：OR=1.01，95%置信区间：0.99-1.02，P=0.363；非过敏性哮喘：OR=1.03，95%置信区间：0.98-1.07，P=0.235）。敏感性分析和各种统计方法结果的一致性支持了这一结论。双向MR的证据表明，25(OH)D水平与过敏性或非过敏性哮喘之间均无因果关系。
