Takahashi Y, Takahashi T, Takahashi W, Sato T
Tohoku J Exp Med. 1985 Nov;147(3):301-9. doi: 10.1620/tjem.147.301.
Forty-three autopsy cases with neither history nor anatomic evidence of hepatobiliary or pancreatic diseases were submitted to morphometrical evaluation of the internal diameter of the common hepatic duct. At a cross section of the duct the perimeter length of the mucosal basement membrane was measured to calculate its diameter D to be obtained when it was stretched into a circle. The value of D was found to correlate significantly with age, with the upper rejection limit (5% level) increasingly elevated from 4.8 mm at 20 years to 7.5 mm at 80 years. This implies that the age of patient should be taken into account in judging clinically whether or not bile ducts actually are dilated. The density in the ductal wall of elastic fibers was also determined and was shown to increase as the senile dilatation progressed, a sign of adaptive reinforcement of wall tissue that is liable to gradual hysteresis under chronic tension load.
对43例既无肝胆或胰腺疾病病史也无解剖学证据的尸检病例进行肝总管内径的形态计量学评估。在胆管的横截面上，测量黏膜基底膜的周长以计算其直径D，该直径是将基底膜拉伸成圆形时得到的。发现D值与年龄显著相关，上界拒绝值（5%水平）从20岁时的4.8mm逐渐升高至80岁时的7.5mm。这意味着在临床判断胆管是否真正扩张时应考虑患者的年龄。还测定了胆管壁弹性纤维的密度，结果显示随着老年期扩张的进展密度增加，这是壁组织适应性增强的标志，壁组织在慢性张力负荷下容易逐渐出现滞后现象。
