Department of Radiology, Boston University Medical Center, 820 Harrison Ave, FGH Building, 3rd Floor, Boston, MA, 02118, USA.
Renaissance Imaging Medical Associates, 18436 Roscoe Boulevard, Northridge, CA, 91325, USA.
Abdom Radiol (NY). 2017 Mar;42(3):884-889. doi: 10.1007/s00261-016-0946-x.
To determine whether the diameter of intrahepatic and extrahepatic bile ducts and pancreatic ducts in patients on methadone maintenance therapy is increased when compared with control subjects.
Between January 1, 2000 and March 15, 2013, a total of 97 patients (mean age 49.9, range 22-79, 65 male, 32 female) were identified who were receiving chronic methadone maintenance therapy (MMT) when they underwent imaging with abdominal MRI or a contrast-enhanced abdominopelvic CT. A group of 97 consecutive non-MMT control patients (mean age 51.4, range 21-86, 45 male, 52 female) who underwent imaging with abdominal MRI or contrast-enhanced abdominopelvic CT were identified. Patients with known pancreaticobiliary pathology that may confound biliary ductal measurements were excluded. Blinded interpretation was performed, documenting the diameters of the intrahepatic and extrahepatic bile ducts and pancreatic ducts. Descriptive statistics were performed.
Patients on MMT demonstrated increased bile duct diameter, with an average increase in duct diameter of 2.39 mm for the common bile duct (p < 0.001; 95% CI 1.88-2.90 mm), 1.43 mm for the intrahepatic bile ducts (p < 0.001; 95% CI 1.12-1.74 mm), and 0.90 mm for the pancreatic duct (p < 0.001; 95% CI 0.64-1.16 mm). No statistically significant correlation was found between ductal diameters and the daily dose of methadone.
Patients on methadone maintenance therapy demonstrate significantly increased intra- and extrahepatic bile duct and pancreatic duct diameter when compared with controls. There was no correlation between the dose of methadone and ductal diameter.
确定接受美沙酮维持治疗的患者与对照组相比，其肝内外胆管和胰管直径是否增大。
2000 年 1 月 1 日至 2013 年 3 月 15 日，共确定 97 例（平均年龄 49.9 岁，范围 22-79 岁，65 例男性，32 例女性）正在接受慢性美沙酮维持治疗（MMT）的患者，他们接受了腹部 MRI 或增强型腹盆腔 CT 成像。确定了一组 97 例连续的非 MMT 对照组患者（平均年龄 51.4 岁，范围 21-86 岁，45 例男性，52 例女性），他们接受了腹部 MRI 或增强型腹盆腔 CT 成像。排除了可能影响胆管测量的已知胰胆管病理。进行了盲法解读，记录了肝内外胆管和胰管的直径。进行了描述性统计。
接受 MMT 的患者胆管直径增加，胆总管平均直径增加 2.39mm（p<0.001；95%CI 1.88-2.90mm），肝内胆管直径增加 1.43mm（p<0.001；95%CI 1.12-1.74mm），胰管直径增加 0.90mm（p<0.001；95%CI 0.64-1.16mm）。胆管直径与美沙酮日剂量之间未发现统计学显著相关性。
与对照组相比，接受美沙酮维持治疗的患者肝内外胆管和胰管直径明显增大。美沙酮剂量与胆管直径之间无相关性。
